[HTML][HTML] The fundamental contribution of prof. Stirpe (and his research group) to the broadening of the scientific perspective on xanthine oxidoreductase
Human xanthine oxidoreductase (XOR) is a multilevel regulated enzyme, which has many
physiological functions, but which is also involved in several pathological processes. The …
physiological functions, but which is also involved in several pathological processes. The …
Hypoxia regulates xanthine dehydrogenase activity at pre-and posttranslational levels
LS Terada, D Piermattei, GN Shibao… - Archives of biochemistry …, 1997 - Elsevier
Hypoxia increases the activity of xanthine oxidase (XO) and its precursor, xanthine
dehydrogenase (XDH), but the mechanism of regulation is unclear. In hypoxic Swiss 3T3 …
dehydrogenase (XDH), but the mechanism of regulation is unclear. In hypoxic Swiss 3T3 …
“Repurposing” of xanthine oxidoreductase as a nitrite reductase: a new paradigm for therapeutic targeting in hypertension
RS Khambata, SM Ghosh… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: In contrast to nitric oxide (NO), which has well-established, important effects in
regulation of cardiovascular homeostasis, its oxidative metabolite nitrite has, until recently …
regulation of cardiovascular homeostasis, its oxidative metabolite nitrite has, until recently …
[HTML][HTML] The impact of xanthine oxidase (XO) on hemolytic diseases
HM Schmidt, EE Kelley, AC Straub - Redox Biology, 2019 - Elsevier
Hemolytic diseases are associated with elevated levels of circulating free heme that can
mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly …
mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly …
Xanthine dehydrogenase: An old enzyme with new knowledge and prospects
CH Wang, C Zhang, XH Xing - Bioengineered, 2016 - Taylor & Francis
ABSTRACT Xanthine dehydrogenase (EC 1.17. 1.4, XDH) is a typical and complex
molybdenum-containing flavoprotein which has been extensively studied for over 110 years …
molybdenum-containing flavoprotein which has been extensively studied for over 110 years …
Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model
LV Dissanayake, A Zietara, V Levchenko, DR Spires… - Iscience, 2022 - cell.com
Uric acid (UA) is the final metabolite in purine catabolism in humans. Previous studies have
shown that the dysregulation of UA homeostasis is detrimental to cardiovascular and kidney …
shown that the dysregulation of UA homeostasis is detrimental to cardiovascular and kidney …
Xanthine oxidoreductase in respiratory and cardiovascular disorders
In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been
implicated in the development of tissue oxidative damage in a wide variety of respiratory and …
implicated in the development of tissue oxidative damage in a wide variety of respiratory and …
Modulation of renal xanthine oxidoreductase in aging: gene expression and reactive oxygen species generation.
HY Chung, SH Song, HJ Kim, Y Ikeno… - The journal of nutrition …, 1999 - europepmc.org
Xanthine oxidoreductase (XD: xanthine dehydrogenase+ xanthine oxidase) is a complex
enzyme that catalyzes oxidation of hypoxathine to xanthine, subsequently producing uric …
enzyme that catalyzes oxidation of hypoxathine to xanthine, subsequently producing uric …
Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
T Kusano, D Ehirchiou, T Matsumura, V Chobaz… - Nature …, 2019 - nature.com
Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its
two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during …
two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during …