Xanthine oxidoreductase: a journey from purine metabolism to cardiovascular excitation-contraction coupling
Xanthine oxidoreductase (XOR) is a ubiquitous complex cytosolic molybdoflavoprotein
which controls the rate limiting step of purine catabolism by converting xanthine to uric acid …
which controls the rate limiting step of purine catabolism by converting xanthine to uric acid …
[HTML][HTML] Human Plasma Xanthine Oxidoreductase Activity in Cardiovascular Disease: Evidence from a Population-Based Study
Y Kotozaki, M Satoh, T Nasu, K Tanno, F Tanaka… - Biomedicines, 2023 - mdpi.com
Xanthine oxidoreductase (XOR) and its products contribute to the development of chronic
inflammation and oxidative stress. Excessive XOR activity is believed to promote …
inflammation and oxidative stress. Excessive XOR activity is believed to promote …
Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene
I Kimiyoshi, A Yoshihiro, N Kumi, M Shinsei, H Tatsuo… - Gene, 1993 - Elsevier
The primary structure of human xanthine dehydrogenase (hXDH) was determined by
cloning and sequence analysis of the cDNAs encoding the enzyme. The nucleotide (nt) …
cloning and sequence analysis of the cDNAs encoding the enzyme. The nucleotide (nt) …
Xanthine oxidoreductase inhibitors
K Vickneson, J George - Reactive Oxygen Species: Network …, 2021 - Springer
Xanthine oxidase inhibitors are primarily used in the clinical prevention and treatment of
gout associated with hyperuricemia. The archetypal xanthine oxidase inhibitor, Allopurinol …
gout associated with hyperuricemia. The archetypal xanthine oxidase inhibitor, Allopurinol …
[HTML][HTML] Production of the carbonate radical anion during xanthine oxidase turnover in the presence of bicarbonate
MG Bonini, S Miyamoto, P Di Mascio… - Journal of Biological …, 2004 - ASBMB
Xanthine oxidase is generally recognized as a key enzyme in purine catabolism, but its
structural complexity, low substrate specificity, and specialized tissue distribution suggest …
structural complexity, low substrate specificity, and specialized tissue distribution suggest …
Xanthine oxidase is variably involved in nutritional and physio-pathologic oxidative stress situations
CF Coudray, G Fouret, B Bonafos, M Aoun… - Journal of …, 2013 - hal.science
Background: High random ROS production leads to generalised oxidative stress that is
involved in aging and degenerative diseases, such diabetes or chronic kidney failure. The …
involved in aging and degenerative diseases, such diabetes or chronic kidney failure. The …
[PDF][PDF] Biochemical role of xanthine oxidoreductase and its natural inhibitors: An overview
UR Batchu, K Mandava - International Journal of Pharmacy and …, 2016 - researchgate.net
Xanthine oxidoreductase (XOR) is a widely distributed housekeeping enzyme in mammals
that catalyzes the last two steps in human purine catabolism to produce uric acid. The …
that catalyzes the last two steps in human purine catabolism to produce uric acid. The …
[HTML][HTML] Novel reversible inhibitors of xanthine oxidase targeting the active site of the enzyme
Xanthine oxidase (XO) is a flavoprotein catalysing the oxidation of hypoxanthine to xanthine
and then to uric acid, while simultaneously producing reactive oxygen species. Altered …
and then to uric acid, while simultaneously producing reactive oxygen species. Altered …
[PDF][PDF] Excess circulating free heme triggers immense elevation in plasma xanthine oxidase activity
H Schmidt, E Kelley, A Straub - Free Radical Biology and Medicine, 2018 - academia.edu
Background: Nuclear factor (erythroid-derived 2)-like-2 (NEFL2/Nrf2) is an inducible
transcription factor that is crucial to fight against stress caused by various means (ie …
transcription factor that is crucial to fight against stress caused by various means (ie …