Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15
months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS …

Simple Summary Glioblastoma multiforme is an aggressive grade IV lethal brain tumour with
a median survival of 14 months. Despite surgery to remove the tumour, and subsequent …

Malignant gliomas are the most common primary brain tumors and have poor clinical
prognosis, despite multimodal therapeutic strategies. In recent years, ion channels have …

Ion channels provide the basis for the nervous system's intrinsic electrical activity. Neuronal
excitability is a characteristic property of neurons and is critical for all functions of the …

Malignant gliomas are the most common primary central nervous system tumors and their
prognosis is very poor. In recent years, ion channels have been demonstrated to play …

Background: Glioma refers to the most aggressive tumor in the central nervous system that
starts from support cells or glial cells. The glial cell is the most common cell type in the CNS …

Ion channels, specifically those controlling the flux of potassium across cell membranes,
have recently been shown to exhibit an important role in the pathophysiology of glioma, the …

Simple Summary Glioblastoma is a rapidly progressing brain cancer that is very difficult to
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …

Ion channels are expressed in many cancers and contribute to disease progression. A
number of ion channels are well established as clinical targets for a range of (noncancer) …

Ion channels are critical for cell development and maintaining cell homeostasis. The
perturbation of ion channel function contributes to the development of a broad range of …