[HTML][HTML] ATM kinase dead: From ataxia telangiectasia syndrome to cancer

S Putti, A Giovinazzo, M Merolle, ML Falchetti… - Cancers, 2021 - mdpi.com
Simple Summary Ataxia telangiectasia mutated (ATM) protein plays a pivotal role in the DNA-
damage response through activation of many different molecular targets. Mutations of the …

[HTML][HTML] ATM, a central controller of cellular responses to DNA damage

KK Khanna, MF Lavin, SP Jackson… - Cell Death & …, 2001 - nature.com
Mutations in the ATM gene lead to the genetic disorder ataxia-telangiectasia. ATM encodes
a protein kinase that is mainly distributed in the nucleus of proliferating cells. Recent studies …

ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis

Y Shiloh - Biochemical Society Transactions, 2001 - portlandpress.com
DNA damage is one of the most acute threats to cellular homeostasis and life. The cell
responds to such damage by activating a vast array of responses, ranging from DNA repair …

ATM signalling and cancer

CA Cremona, A Behrens - Oncogene, 2014 - nature.com
ATM, the protein kinase mutated in the rare human disease ataxia telangiectasia (AT), has
been the focus of intense scrutiny over the past two decades. Initially this was because of the …

ATM and ataxia telangiectasia: second in molecular medicine review series

PJ McKinnon - EMBO reports, 2004 - embopress.org
Ataxia telangiectasia (AT) has long intrigued the biomedical research community owing to
the spectrum of defects that are characteristic of the disease, including neurodegeneration …

Clinical potential of ATM inhibitors

MF Lavin, AJ Yeo - … Research/Fundamental and Molecular Mechanisms of …, 2020 - Elsevier
The protein defective in the human genetic disorder ataxia-telangiectasia, ATM, plays a
central role in responding to DNA double strand breaks and other lesions to protect the …

ATM dependent apoptosis in the nervous system

Y Lee, PJ McKinnon - Apoptosis, 2000 - Springer
Ataxia-telangiectasia is a human syndrome resulting from mutations of the ATM protein
kinase that is characterized by radiation sensitivity and neurodegeneration. Although …

ATM: the product of the gene mutated in ataxia-telangiectasia

MF Lavin - The International Journal of Biochemistry & Cell …, 1999 - Elsevier
Ataxia-telangiectasia mutated (ATM) is the product of the gene mutated in the human
genetic disorder ataxia-telangeictasia (AT). It is a 370 kDa protein that is a member of the …

ATM and related protein kinases: safeguarding genome integrity

Y Shiloh - Nature reviews cancer, 2003 - nature.com
Maintenance of genome stability is essential for avoiding the passage to neoplasia. The
DNA-damage response—a cornerstone of genome stability—occurs by a swift transduction …

The ATM gene and protein: possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress.

G Rotman, Y Shiloh - Cancer surveys, 1997 - europepmc.org
The autosomal recessive disorder ataxia-telangiectasia (AT) is highly pleiotropic. It is
characterized by gradual loss of Purkinje cells in the cerebellum, leading to progressive …