Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide

G Khelashvili, A Plante, M Doktorova, H Weinstein - Biophysical Journal, 2021 - cell.com
Cell penetration after recognition of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) virus by the ACE2 receptor and the fusion of its viral envelope membrane …

Binding mode of SARS-CoV-2 fusion peptide to human cellular membrane

D Gorgun, M Lihan, K Kapoor, E Tajkhorshid - Biophysical journal, 2021 - cell.com
Infection of human cells by the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV2) relies on its binding to a specific receptor and subsequent fusion of the viral and host …

Mechanistic insights of host cell fusion of SARS-CoV-1 and SARS-CoV-2 from atomic resolution structure and membrane dynamics

H Chakraborty, S Bhattacharjya - Biophysical Chemistry, 2020 - Elsevier
The emerging and re-emerging viral diseases are continuous threats to the wellbeing of
human life. Previous outbreaks of Severe Acute Respiratory Syndrome (SARS) and Middle …

Strikingly different roles of SARS-CoV-2 fusion peptides uncovered by neutron scattering

A Santamaria, KC Batchu, O Matsarskaia… - Journal of the …, 2022 - ACS Publications
Coronavirus disease-2019 (COVID-19), a potentially lethal respiratory illness caused by the
coronavirus SARS-CoV-2, emerged in the end of 2019 and has since spread aggressively …

Binding of SARS-CoV-2 fusion peptide to host endosome and plasma membrane

SL Schaefer, H Jung, G Hummer - The journal of physical …, 2021 - ACS Publications
During infection the SARS-CoV-2 virus fuses its viral envelope with cellular membranes of
its human host. The viral spike (S) protein mediates both the initial contact with the host cell …

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

J Yang, SJL Petitjean, M Koehler, Q Zhang… - Nature …, 2020 - nature.com
Study of the interactions established between the viral glycoproteins and their host receptors
is of critical importance for a better understanding of virus entry into cells. The novel …

Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain

M Monti, E Milanetti, MT Frans, M Miotto… - The Journal of …, 2024 - ACS Publications
It is not well understood why severe acute respiratory syndrome (SARS)-CoV-2 spreads
much faster than other β-coronaviruses such as SARS-CoV and Middle East respiratory …

Computational insight into the mechanism of SARS-CoV-2 membrane fusion

S Borkotoky, D Dey, M Banerjee - Journal of Chemical Information …, 2021 - ACS Publications
Membrane fusion, a key step in the early stages of virus propagation, allows the release of
the viral genome in the host cell cytoplasm. The process is initiated by fusion peptides that …

Host cell membrane capture by the SARS-CoV-2 spike protein fusion intermediate

R Su, J Zeng, TC Marcink, M Porotto… - ACS Central …, 2023 - ACS Publications
Cell entry by SARS-CoV-2 is accomplished by the S2 subunit of the spike S protein on the
virion surface by capture of the host cell membrane and fusion with the viral envelope …

SARS-CoV-2 fusion peptide has a greater membrane perturbating effect than SARS-CoV with highly specific dependence on Ca2+

AL Lai, JH Freed - Journal of Molecular Biology, 2021 - Elsevier
Coronaviruses are a major infectious disease threat, and include the zoonotic-origin human
pathogens SARS-CoV-2, SARS-CoV, and MERS-CoV (SARS-2, SARS-1, and MERS). Entry …