Background Patients with critical limb ischemia (CLI) still have a high rate of lower limb
amputation, which is associated with not only a decrease in quality of life but also poor life …

Adipose-derived regenerative cell (ADRC) is a promising alternative source of autologous
somatic stem cells for the repair of damaged tissue. This study aimed to assess the safety …

Background aims Non-revascularizable critical limb ischemia (CLI) is the most severe stage
of peripheral arterial disease, with no therapeutic option. Extensive preclinical studies have …

Background: Treatment of critical limb ischemia (CLI) by bypass operation or percutaneous
vascular intervention is occasionally difficult. The safety and efficacy of multiple …

Therapeutic angiogenesis is an important strategy to rescue ischemic tissues in patients with
critical limb ischemia having no other treatment option such as endovascular angioplasty or …

Background Cell-based therapy is being explored as an alternative treatment option for
critical limb ischemia (CLI), a disease associated with high amputation and mortality rates …

Therapeutic angiogenesis has emerged as one of the most promising therapies for severe
ischemic cardiovascular diseases with no optional therapy. Several investigators have …

Objective—The delivery of autologous progenitor cells into ischemic tissue of patients is
emerging as a novel therapeutic option. Here, we report the potential impact of cultured …

Peripheral artery disease is growing in global prevalence. Its most severe form, critical limb
ischemia (CLI), is associated with high rates of limb loss, morbidity, and mortality …

Background Chronic lower limb ischemia develops earlier and more frequently in patients
with type 2 diabetes mellitus. Diabetes remains the main cause of lower-extremity non …