Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive
upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar …

While primary lateral sclerosis (PLS) has traditionally been regarded as a pure upper motor
neuron disorder, recent clinical, neuroimaging and postmortem studies have confirmed …

Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …

Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Background Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …

Background: Primary lateral sclerosis (PLS) is an idiopathic upper motor neuron
degenerative disorder. The aim of this study was to compare brain volumes in patients with …

Objectives This is a cross-sectional study aimed at investigating cognitive performances in
patients with primary lateral sclerosis (PLS) and using diffusion tensor (DT) magnetic …

Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The
clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor …

Primary lateral sclerosis and amyotrophic lateral sclerosis are primarily associated with
motor cortex and corticospinal tract pathology. A standardised, prospective, single-centre …