Gene expression of diverse Cryptococcus isolates during infection of the human central nervous system

CH Yu, P Sephton-Clark, JL Tenor, DL Toffaletti… - Mbio, 2021 - Am Soc Microbiol
Cryptococcus neoformans is a major human central nervous system (CNS) fungal pathogen
causing considerable morbidity and mortality. In this study, we provide the widest view to …

The Cryptococcus neoformans transcriptome at the site of human meningitis

Y Chen, DL Toffaletti, JL Tenor, AP Litvintseva, C Fang… - MBio, 2014 - Am Soc Microbiol
Cryptococcus neoformans is the leading cause of fungal meningitis worldwide. Previous
studies have characterized the cryptococcal transcriptome under various stress conditions …

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses

CH Yu, Y Chen, CA Desjardins, JL Tenor… - Microbial …, 2020 - microbiologyresearch.org
Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …

Genomic variation across a clinical Cryptococcus population linked to disease outcome

P Sephton-Clark, JL Tenor, DL Toffaletti, N Meyers… - Mbio, 2022 - Am Soc Microbiol
Cryptococcus neoformans is the causative agent of cryptococcosis, a disease with poor
patient outcomes that accounts for approximately 180,000 deaths each year. Patient …

Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii

Y Chen, RA Farrer, C Giamberardino, S Sakthikumar… - MBio, 2017 - Am Soc Microbiol
The pathogenic species of Cryptococcus are a major cause of mortality owing to severe
infections in immunocompromised as well as immunocompetent individuals. Although …

[HTML][HTML] Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A

JMH Geddes, D Croll, M Caza, N Stoynov, LJ Foster… - BMC microbiology, 2015 - Springer
Abstract Background The pathogenic yeast Cryptococcus neoformans causes life-
threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic …

Identification of pathogen genomic differences that impact human immune response and disease during Cryptococcus neoformans infection

AC Gerstein, KM Jackson, TR McDonald, Y Wang… - MBio, 2019 - Am Soc Microbiol
Patient outcomes during infection are due to a complex interplay between the quality of
medical care, host immunity factors, and the infecting pathogen's characteristics. To probe …

Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis

BR Steen, S Zuyderduyn, DL Toffaletti, M Marra… - Eukaryotic …, 2003 - Am Soc Microbiol
Cryptococcus neoformans, an encapsulated basidiomycete fungus of medical importance, is
capable of crossing the blood-brain barrier and causing meningitis in both …

Dynamics of Cryptococcus neoformans-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in …

A Alanio, M Desnos-Ollivier, F Dromer - MBio, 2011 - Am Soc Microbiol
Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and
outcome. As in many infectious diseases, this variability is commonly assigned to host …

[HTML][HTML] Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans

KT Lee, J Hong, DG Lee, M Lee, S Cha, YG Lim… - Nature …, 2020 - nature.com
Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …