Gene expression of diverse Cryptococcus isolates during infection of the human central nervous system
CH Yu, P Sephton-Clark, JL Tenor, DL Toffaletti… - Mbio, 2021 - Am Soc Microbiol
Cryptococcus neoformans is a major human central nervous system (CNS) fungal pathogen
causing considerable morbidity and mortality. In this study, we provide the widest view to …
causing considerable morbidity and mortality. In this study, we provide the widest view to …
The Cryptococcus neoformans transcriptome at the site of human meningitis
Y Chen, DL Toffaletti, JL Tenor, AP Litvintseva, C Fang… - MBio, 2014 - Am Soc Microbiol
Cryptococcus neoformans is the leading cause of fungal meningitis worldwide. Previous
studies have characterized the cryptococcal transcriptome under various stress conditions …
studies have characterized the cryptococcal transcriptome under various stress conditions …
Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses
Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …
Genomic variation across a clinical Cryptococcus population linked to disease outcome
P Sephton-Clark, JL Tenor, DL Toffaletti, N Meyers… - Mbio, 2022 - Am Soc Microbiol
Cryptococcus neoformans is the causative agent of cryptococcosis, a disease with poor
patient outcomes that accounts for approximately 180,000 deaths each year. Patient …
patient outcomes that accounts for approximately 180,000 deaths each year. Patient …
Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii
The pathogenic species of Cryptococcus are a major cause of mortality owing to severe
infections in immunocompromised as well as immunocompetent individuals. Although …
infections in immunocompromised as well as immunocompetent individuals. Although …
[HTML][HTML] Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A
Abstract Background The pathogenic yeast Cryptococcus neoformans causes life-
threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic …
threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic …
Identification of pathogen genomic differences that impact human immune response and disease during Cryptococcus neoformans infection
AC Gerstein, KM Jackson, TR McDonald, Y Wang… - MBio, 2019 - Am Soc Microbiol
Patient outcomes during infection are due to a complex interplay between the quality of
medical care, host immunity factors, and the infecting pathogen's characteristics. To probe …
medical care, host immunity factors, and the infecting pathogen's characteristics. To probe …
Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis
BR Steen, S Zuyderduyn, DL Toffaletti, M Marra… - Eukaryotic …, 2003 - Am Soc Microbiol
Cryptococcus neoformans, an encapsulated basidiomycete fungus of medical importance, is
capable of crossing the blood-brain barrier and causing meningitis in both …
capable of crossing the blood-brain barrier and causing meningitis in both …
Dynamics of Cryptococcus neoformans-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in …
A Alanio, M Desnos-Ollivier, F Dromer - MBio, 2011 - Am Soc Microbiol
Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and
outcome. As in many infectious diseases, this variability is commonly assigned to host …
outcome. As in many infectious diseases, this variability is commonly assigned to host …
[HTML][HTML] Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans
Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …