Once activated by ligand, epidermal growth factor receptor (EGFR) is endocytosed in
clathrin-coated pits. ITCH is an E3 ubiquitin ligase that interacts with and ubiquitinates …

EGF-mediated stimulation of the EGF receptor activates a plethora of signaling cascades
followed by receptor down regulation. Preventing down regulation leads to increased …

Endophilin A1 is an SH3 domain-containing protein functioning in membrane trafficking on
the endocytic pathway. We have identified the E3 ubiquitin ligase itch/AIP4 as an endophilin …

Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of
EGFR signaling. However, EGFR endocytosis mechanisms are poorly understood, which …

Clathrin-mediated endocytosis (CME) is the major pathway of epidermal growth factor
receptor (EGFR) internalization. It is commonly believed that CME mediates long-term …

The roles of EGF receptor (EGFR) kinase activity and ubiquitination in EGFR endocytosis
have been controversial. The adaptor protein and ubiquitin ligase Cbl has reportedly been …

Clathrin-mediated endocytosis (CME) involves spatially and temporally restricted molecular
dynamics, to which protein kinases and actin contribute. However, whether and how these …

The removal of the epidermal growth factor receptor (EGFR) from the cell surface by
endocytosis is triggered by receptor activation, but many facets of EGFR trafficking remain …

Ligand binding triggers clathrin-mediated and, at high ligand concentrations, clathrin-
independent endocytosis of EGFR. Clathrin-mediated endocytosis (CME) of EGFR is also …

We have demonstrated previously that c-Cbl requires the presence of a functional ubiquitin
interacting motif (UIM) in Eps15 to mediate epidermal growth factor receptor (EGFR) …