[HTML][HTML] Does prolonged infusion time really improve the efficacy of meropenem therapy? A prospective study in critically ill patients
YC Zhao, Y Zou, YW Xiao, F Wang, BK Zhang… - Infectious Diseases and …, 2022 - Springer
Introduction Meropenem is a carbapenem antibiotic, which has demonstrated excellent
antimicrobial activity against gram-negative clinical isolates. It is also commonly used in …
antimicrobial activity against gram-negative clinical isolates. It is also commonly used in …
Meropenem pharmacokinetics and target attainment in critically ill patients
Y Gan, X Meng, N Lei, H Yu, Q Zeng… - Infection and Drug …, 2023 - Taylor & Francis
Purpose This study aimed to investigate the pharmacokinetics and target attainment of
meropenem and compare the effect of meropenem dosing regimens in critically ill patients …
meropenem and compare the effect of meropenem dosing regimens in critically ill patients …
Population pharmacokinetics and pharmacodynamics of meropenem in critically ill patients: how to achieve best dosage regimen according to the clinical situation
A O'jeanson, R Larcher, C Le Souder, N Djebli… - European journal of …, 2021 - Springer
Abstract Background and Objectives Meropenem is frequently used for the treatment of
severe bacterial infections in critically ill patients. Because critically ill patients are more …
severe bacterial infections in critically ill patients. Because critically ill patients are more …
Development of a dosing algorithm for meropenem in critically ill patients based on a population pharmacokinetic/pharmacodynamic analysis
L Ehmann, M Zoller, IK Minichmayr, C Scharf… - International journal of …, 2019 - Elsevier
Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …
Population pharmacokinetics/pharmacodynamics and clinical outcomes of meropenem in critically ill patients
A Boonpeng, S Jaruratanasirikul… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …
Identification of factors affecting meropenem pharmacokinetics in critically ill patients: impact of inflammation on clearance
Y Niibe, T Suzuki, S Yamazaki, M Uchida… - Journal of Infection and …, 2022 - Elsevier
Introduction The purpose of this study was to explore factors influencing meropenem
pharmacokinetics (PKs) in critically ill patients by developing a population PK model and to …
pharmacokinetics (PKs) in critically ill patients by developing a population PK model and to …
Effectiveness of pharmacokinetic/pharmacodynamic-guided meropenem treatment in critically ill patients: a comparative cohort study
A Aldaz, AII Grijalba, A Ortega, I Aquerreta… - Therapeutic drug …, 2021 - journals.lww.com
Background: The proper dosage of antibiotics is a key element in the effective treatment of
infection, especially in critically ill patients. This study aimed to evaluate the efficacy of …
infection, especially in critically ill patients. This study aimed to evaluate the efficacy of …
[HTML][HTML] Assessment of pharmacokinetic changes of meropenem during therapy in septic critically ill patients
J Goncalves-Pereira, NE Silva, A Mateus… - BMC Pharmacology and …, 2014 - Springer
Background Meropenem is a carbapenem antibiotic commonly used in critically ill patients
to treat severe infections. The available pharmacokinetic (PK) data has been mostly …
to treat severe infections. The available pharmacokinetic (PK) data has been mostly …
[HTML][HTML] Factors associated with meropenem pharmacokinetic/pharmacodynamic target attainment in septic critically ill patients treated with extended intermittent …
S Tournayre, O Mathieu, M Villiet, N Besnard… - International Journal of …, 2023 - Elsevier
Objectives The use of extended intermittent infusion (EII) or continuous infusion (CI) of
meropenem is recommended in intensive care unit (ICU) patients, but few data comparing …
meropenem is recommended in intensive care unit (ICU) patients, but few data comparing …
Population pharmacokinetics of meropenem in critically ill patients undergoing continuous renal replacement therapy
A Isla, A Rodríguez-Gascón, IF Trocóniz… - Clinical …, 2008 - Springer
Background and objective: Meropenem is a carbapenem antibacterial frequently prescribed
for the treatment of severe infections in critically ill patients, including those receiving …
for the treatment of severe infections in critically ill patients, including those receiving …