[HTML][HTML] Functional phenotyping of microglia highlights the dark relationship between chronic traumatic brain injury and normal age-related pathology

RM Ritzel, J Wu - Neural regeneration research, 2023 - journals.lww.com
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Age-related
TBI differences demonstrate the third peak of prevalence and incidence of TBI within the …

[HTML][HTML] Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration

F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …

[HTML][HTML] Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice

RM Ritzel, Y Li, Z Lei, J Carter, J He, HMC Choi… - Geroscience, 2022 - Springer
Elderly patients with traumatic brain injury (TBI) have greater mortality and poorer outcomes
than younger individuals. The extent to which old age alters long-term recovery and chronic …

Microglia and infiltrating T-cells adopt long-term, age-specific, transcriptional changes after traumatic brain injury in mice

Z Chen, MBAR Islam, KP Ford, G Zhao, SY Chen… - Shock, 2023 - journals.lww.com
Aged traumatic brain injury (TBI) patients suffer increased mortality and long-term
neurocognitive and neuropsychiatric morbidity compared with younger patients. Microglia …

Cellular players that shape evolving pathology and neurodegeneration following traumatic brain injury

SS Puntambekar, M Saber, BT Lamb… - Brain, behavior, and …, 2018 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide,
and has emerged as a critical risk factor for multiple neurodegenerative diseases …

[HTML][HTML] Microglial activation in traumatic brain injury

CK Donat, G Scott, SM Gentleman… - Frontiers in aging …, 2017 - frontiersin.org
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …

[HTML][HTML] Microglia activation as a biomarker for traumatic brain injury

DG Hernandez-Ontiveros, N Tajiri, S Acosta… - Frontiers in …, 2013 - frontiersin.org
Traumatic brain injury (TBI) has become the signature wound of wars in Afghanistan and
Iraq. Injury may result from a mechanical force, a rapid acceleration-deceleration movement …

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

A Kumar, BA Stoica, B Sabirzhanov, MP Burns… - Neurobiology of …, 2013 - Elsevier
Traumatic brain injury (TBI) causes chronic microglial activation that contributes to
subsequent neurodegeneration, with clinical outcomes declining as a function of aging …

[HTML][HTML] Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury

JM Morganti, LK Riparip, A Chou, S Liu… - Journal of …, 2016 - Springer
Background Traumatic brain injury (TBI) is a major risk factor for the development of multiple
neurodegenerative diseases, including Alzheimer's disease (AD) and numerous recent …

[HTML][HTML] Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research

MR Grovola, C von Reyn, DJ Loane… - Journal of …, 2023 - Springer
Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with
over 2.8 million affected annually in the US, including over 56,000 deaths, with over 5 million …