[HTML][HTML] Functional phenotyping of microglia highlights the dark relationship between chronic traumatic brain injury and normal age-related pathology
RM Ritzel, J Wu - Neural regeneration research, 2023 - journals.lww.com
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Age-related
TBI differences demonstrate the third peak of prevalence and incidence of TBI within the …
TBI differences demonstrate the third peak of prevalence and incidence of TBI within the …
[HTML][HTML] Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration
F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …
[HTML][HTML] Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice
Elderly patients with traumatic brain injury (TBI) have greater mortality and poorer outcomes
than younger individuals. The extent to which old age alters long-term recovery and chronic …
than younger individuals. The extent to which old age alters long-term recovery and chronic …
Microglia and infiltrating T-cells adopt long-term, age-specific, transcriptional changes after traumatic brain injury in mice
Aged traumatic brain injury (TBI) patients suffer increased mortality and long-term
neurocognitive and neuropsychiatric morbidity compared with younger patients. Microglia …
neurocognitive and neuropsychiatric morbidity compared with younger patients. Microglia …
Cellular players that shape evolving pathology and neurodegeneration following traumatic brain injury
Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide,
and has emerged as a critical risk factor for multiple neurodegenerative diseases …
and has emerged as a critical risk factor for multiple neurodegenerative diseases …
[HTML][HTML] Microglial activation in traumatic brain injury
CK Donat, G Scott, SM Gentleman… - Frontiers in aging …, 2017 - frontiersin.org
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …
mediating the immune response against peripheral infection. Microglia rapidly become …
[HTML][HTML] Microglia activation as a biomarker for traumatic brain injury
DG Hernandez-Ontiveros, N Tajiri, S Acosta… - Frontiers in …, 2013 - frontiersin.org
Traumatic brain injury (TBI) has become the signature wound of wars in Afghanistan and
Iraq. Injury may result from a mechanical force, a rapid acceleration-deceleration movement …
Iraq. Injury may result from a mechanical force, a rapid acceleration-deceleration movement …
Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
Traumatic brain injury (TBI) causes chronic microglial activation that contributes to
subsequent neurodegeneration, with clinical outcomes declining as a function of aging …
subsequent neurodegeneration, with clinical outcomes declining as a function of aging …
[HTML][HTML] Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury
Background Traumatic brain injury (TBI) is a major risk factor for the development of multiple
neurodegenerative diseases, including Alzheimer's disease (AD) and numerous recent …
neurodegenerative diseases, including Alzheimer's disease (AD) and numerous recent …
[HTML][HTML] Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research
MR Grovola, C von Reyn, DJ Loane… - Journal of …, 2023 - Springer
Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with
over 2.8 million affected annually in the US, including over 56,000 deaths, with over 5 million …
over 2.8 million affected annually in the US, including over 56,000 deaths, with over 5 million …