Mammalian PERIOD2 regulates H2A. Z incorporation in chromatin to orchestrate circadian negative feedback
Mammalian circadian oscillators are built on a feedback loop in which the activity of the
transcription factor CLOCK–BMAL1 is repressed by the PER–CRY complex. Here, we show …
transcription factor CLOCK–BMAL1 is repressed by the PER–CRY complex. Here, we show …
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes
The mammalian circadian clock is built on a molecular feedback loop in which the Period
(PER) proteins, acting in a large, poorly understood complex, repress Clock–Bmal1, the …
(PER) proteins, acting in a large, poorly understood complex, repress Clock–Bmal1, the …
Histone monoubiquitination by Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback
Circadian rhythms in mammals are driven by a feedback loop in which the transcription
factor Clock–Bmal1 activates expression of Per and Cry proteins, which together form a …
factor Clock–Bmal1 activates expression of Per and Cry proteins, which together form a …
A molecular mechanism for circadian clock negative feedback
Circadian rhythms in mammals are generated by a feedback loop in which the three
PERIOD (PER) proteins, acting in a large complex, inhibit the transcriptional activity of the …
PERIOD (PER) proteins, acting in a large complex, inhibit the transcriptional activity of the …
Circadian and Light-Induced Transcription of Clock Gene Per1 Depends on Histone Acetylation and Deacetylation
Y Naruse, K Oh-hashi, N Iijima, M Naruse… - … and cellular biology, 2004 - Taylor & Francis
Circadian clock genes are regulated through a transcriptional-translational feedback loop.
Alterations of the chromatin structure by histone acetyltransferases and histone …
Alterations of the chromatin structure by histone acetyltransferases and histone …
[PDF][PDF] Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor
Mammalian circadian rhythms are generated by a negative feedback loop in which PERIOD
(PER) proteins accumulate, form a large nuclear complex (PER complex), and bind the …
(PER) proteins accumulate, form a large nuclear complex (PER complex), and bind the …
CLOCK: BMAL1 is a pioneer-like transcription factor
JS Menet, S Pescatore, M Rosbash - Genes & development, 2014 - genesdev.cshlp.org
The mammalian circadian clock relies on the master genes CLOCK and BMAL1 to drive
rhythmic gene expression and regulate biological functions under circadian control. Here we …
rhythmic gene expression and regulate biological functions under circadian control. Here we …
[PDF][PDF] Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism
Circadian rhythms in mammals are generated by a transcriptional negative feedback loop
that is driven primarily by oscillations of PER and CRY, which inhibit their own transcriptional …
that is driven primarily by oscillations of PER and CRY, which inhibit their own transcriptional …
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
JA Ripperger, U Schibler - Nature genetics, 2006 - nature.com
Mammalian circadian rhythms are based on transcriptional and post-translational feedback
loops. Essentially, the activity of the transcription factors BMAL1 (also known as MOP3) and …
loops. Essentially, the activity of the transcription factors BMAL1 (also known as MOP3) and …
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
Rhythmic gene expression is central to the circadian control of physiology in mammals.
Transcriptional activation of Per and Cry genes by heterodimeric bHLH-PAS proteins is a …
Transcriptional activation of Per and Cry genes by heterodimeric bHLH-PAS proteins is a …