Significance: A decline in both cognitive and motor functions is one of the characteristics of
aging. This results in changes in learning and memory, as well as deficits in balance and …

Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …

For the past 60 years a major theory of “aging” is that age-related damage is largely caused
by excessive uncompensated oxidative stress. The ubiquitous tripeptide glutathione is a …

Aging is characterized by a gradual decline of the body's biological functions, which can
lead to increased production of reactive oxygen species (ROS). Antioxidants neutralize ROS …

Brain markers of oxidative damage increase with advancing age. In response, brain
antioxidant levels may also increase with age, although this has not been well investigated …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

Loss of brain glutathione has been associated with cognitive decline and neuronal death
during aging and neurodegenerative diseases. However, whether decreased glutathione …

The most reliable and robust risk factor for some neurodegenerative diseases is aging. It has
been proposed that processes of aging are associated with the generation of reactive …

The main purpose of the present study was to determine whether specific regions of the
mouse brain exhibit different age-related changes in oxidative stress, as indicated by …

Glutathione plays a critical role in many biological processes both directly as a co-factor in
enzymatic reactions and indirectly as the major thiol-disulfide redox buffer in mammalian …