The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG

L Chen, M Zhang, P Chen, X Xiong, P Liu… - Acta Pharmacologica …, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is the most abundant posttranscriptional methylation
modification that occurs in mRNA and modulates the fine-tuning of various biological …

m6A demethylase FTO and osteoporosis: Potential therapeutic interventions

M Huang, J Guo, L Liu, H Jin, X Chen… - Frontiers in Cell and …, 2023 - frontiersin.org
Osteoporosis is a common bone disease, characterized by a descent in bone mass due to
the dysregulation of bone homeostasis. Although different studies have identified an …

Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis

X Chen, W Hua, X Huang, Y Chen, J Zhang… - Frontiers in …, 2020 - frontiersin.org
Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone
structure is destroyed to the degree that bone becomes fragile and prone to fractures …

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

Y Wu, L Xie, M Wang, Q Xiong, Y Guo, Y Liang… - Nature …, 2018 - nature.com
Abstract N6-methyladenosine (m6A) is the most abundant epigenetic modification in
eukaryotic mRNAs and is essential for multiple RNA processing events during mammalian …

m6A methylation regulates osteoblastic differentiation and bone remodeling

M Huang, S Xu, L Liu, M Zhang, J Guo… - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a prevalent bone disease of the aging population, which is characterized by
a decrease in bone mass because of the imbalance of bone metabolism. Although the …

The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis

Y Li, L Meng, B Zhao - Pharmacology & therapeutics, 2022 - Elsevier
Abstract N 6-methyladenosine (m 6 A), a novel epitranscriptomic RNA modification, plays
crucial roles in a variety of biological processes and diseases. Recently, there are growing …

[HTML][HTML] RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation

J Wang, Q Fu, J Yang, JL Liu, SM Hou, X Huang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
As a systemic disease, osteoporosis (OP) results in bone density loss and fracture risk,
particularly in the hip and vertebrae. However, the underlying molecular mechanisms of OP …

METTL14 upregulates TCF1 through m6A mRNA methylation to stimulate osteogenic activity in osteoporosis

X Wang, C Zou, M Li, C Hou, W Jiang, Z Bian, L Zhu - Human Cell, 2023 - Springer
Alteration of N6-methyladenosine (m6A) is closely linked to spanning biological processes
including osteoporosis (OP) development. This research focuses on the function of …

[HTML][HTML] The essential roles of m6A modification in osteogenesis and common bone diseases

Y Gu, Y Song, Y Pan, J Liu - Genes & Diseases, 2024 - Elsevier
Abstract N6-methyladenosine (m 6 A) is the most prevalent modification in the eukaryotic
transcriptome and has a wide range of functions in coding and noncoding RNAs. It affects …

The N6-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6

Z Li, P Wang, J Li, Z Xie, S Cen, M Li, W Liu, G Ye… - Cell Death & …, 2021 - nature.com
Abstract N 6-methyladenosine (m6A) modification is widespread in messenger RNAs and
increasing evidence suggests the crucial roles of m6A in cell differentiation and tissue …