[HTML][HTML] Resistance of oral squamous cell carcinoma cells to cetuximab is associated with EGFR insensitivity and enhanced stem cell-like potency
Y Ohnishi, Y Minamino, K Kakudo… - Oncology …, 2014 - spandidos-publications.com
Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is
used in cancer treatment. Although development of resistance to cetuximab is well …
used in cancer treatment. Although development of resistance to cetuximab is well …
[HTML][HTML] Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR …
Y Ohnishi, H Yasui, K Kakudo… - … Journal of Oncology, 2015 - spandidos-publications.com
We have previously shown that growth of the oral squamous cell carcinoma cell line SAS, is
resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor …
resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor …
Relationship between EGFR expression in oral cancer cell lines and cetuximab antibody-dependent cell-mediated cytotoxicity
H Nakamura, S Tamaki, T Yagyuu… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: Cetuximab treatment targets the epidermal growth factor receptor (EGFR)
overexpressed in oral cancer. This study aimed to investigate the anti-tumour activity of …
overexpressed in oral cancer. This study aimed to investigate the anti-tumour activity of …
Cetuximab inhibits oral squamous cell carcinoma invasion and metastasis via degradation of epidermal growth factor receptor
W Dai, Y Li, Q Zhou, Z Xu, C Sun… - Journal of oral …, 2014 - Wiley Online Library
Cetuximab (Erbitux, C225) is a chimeric monoclonal antibody that binds to the extracellular
domain of epidermal growth factor receptor (EGFR), inhibiting tumor growth, invasion …
domain of epidermal growth factor receptor (EGFR), inhibiting tumor growth, invasion …
[HTML][HTML] Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma
H Yang, C Mo, Y Xun, LG Liu, W Li, J Guan… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Objective: To investigate the underlying molecular mechanisms contributing to oral
squamous cell carcinoma (OSCC) cell resistance to the epidermal growth factor receptor …
squamous cell carcinoma (OSCC) cell resistance to the epidermal growth factor receptor …
Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance
M Rebucci, P Peixoto, A Dewitte… - International …, 2011 - spandidos-publications.com
EGFR is frequently overexpressed in head and neck squamous cell cancer (HNSCC).
Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation …
Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation …
Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment‐induced reduction in EGFR, p EGFR, and pSrc
A Jedlinski, S Garvin, AC Johansson… - Journal of Oral …, 2017 - Wiley Online Library
Background The aims of this study were to validate in vitro drug sensitivity testing of head
and neck squamous cell carcinoma (HNSCC) cell lines in an in vivo xenograft model and to …
and neck squamous cell carcinoma (HNSCC) cell lines in an in vivo xenograft model and to …
Differential escape mechanisms in cetuximab-resistant head and neck cancer cells
CD Willey, JC Anderson, HQ Trummell, F Naji… - Biochemical and …, 2019 - Elsevier
Acquired cetuximab resistance is a challenge for oncologists treating advanced head and
neck carcinoma (HNC). While intrinsic cetuximab resistance mechanism in colorectal cancer …
neck carcinoma (HNC). While intrinsic cetuximab resistance mechanism in colorectal cancer …
[HTML][HTML] Anti-EGFR antibody cetuximab is secreted by oral squamous cell carcinoma and alters EGF-driven mesenchymal transition
T Fujiwara, T Eguchi, C Sogawa, K Ono… - Biochemical and …, 2018 - Elsevier
Genetic amplification, overexpression, and increased signaling from the epidermal growth
factor receptor (EGFR) are often found in oral squamous cell carcinoma (OSCC) and thus …
factor receptor (EGFR) are often found in oral squamous cell carcinoma (OSCC) and thus …
[HTML][HTML] Insulin growth factor 1 like receptor (IGF-1R)
G Iyer, J Price, S Bourgeois, E Armstrong, S Huang… - BMC cancer, 2016 - Springer
Background The epidermal growth factor receptor (EGFR) is frequently overexpressed in
head and neck squamous cell carcinoma (HNSCC) and several other human cancers …
head and neck squamous cell carcinoma (HNSCC) and several other human cancers …