Unraveling the pathophysiology of schizophrenia: insights from structural magnetic resonance imaging studies

MJ Adamu, L Qiang, CO Nyatega, A Younis… - Frontiers in …, 2023 - frontiersin.org
Background Schizophrenia affects about 1% of the global population. In addition to the
complex etiology, linking this illness to genetic, environmental, and neurobiological factors …

Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study

CL Shen, SJ Tsai, CP Lin, AC Yang - Schizophrenia, 2023 - nature.com
Schizophrenia is a chronic brain disorder, and neuroimaging abnormalities have been
reported in different stages of the illness for decades. However, when and how these brain …

Are there progressive brain changes in schizophrenia? A meta-analysis of structural magnetic resonance imaging studies

B Olabi, I Ellison-Wright, AM McIntosh, SJ Wood… - Biological …, 2011 - Elsevier
Background It is well established that schizophrenia is associated with structural brain
abnormalities, but whether these are static or progress over time remains controversial …

Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder

E Schwarz, NT Doan, G Pergola, LT Westlye… - Translational …, 2019 - nature.com
Schizophrenia is a severe mental disorder characterized by numerous subtle changes in
brain structure and function. Machine learning allows exploring the utility of combining …

Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real‐world multisite study

K Nemoto, T Shimokawa, M Fukunaga… - Psychiatry and …, 2020 - Wiley Online Library
Aim Neuroimaging studies have revealed that patients with schizophrenia exhibit reduced
gray matter volume in various regions. With these findings, various studies have indicated …

Gray matter volume changes following antipsychotic therapy in first-episode schizophrenia patients: a longitudinal voxel-based morphometric study

F Guo, YQ Zhu, C Li, XR Wang, HN Wang… - Journal of psychiatric …, 2019 - Elsevier
Despite evidence of structural brain abnormalities in schizophrenia, the current study aimed
to explore the effects of antipsychotic treatment on gray matter (GM) volume using structural …

Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: modeling head motion and neuroanatomical specificity

N Yao, AM Winkler, J Barrett, GA Book… - Human brain …, 2017 - Wiley Online Library
Despite over 400 peer‐reviewed structural MRI publications documenting neuroanatomic
abnormalities in bipolar disorder and schizophrenia, the confounding effects of head motion …

Brain morphology in antipsychotic-naive schizophrenia: a study of multiple brain structures

W Cahn, HEH Pol, M Bongers, HG Schnack… - The British Journal of …, 2002 - cambridge.org
BackgroundAlthough brain volume changes are found in schizophrenia, only a limited
number of structural magnetic resonance imaging studies have exclusively examined …

Grey matter changes over time in high risk subjects developing schizophrenia

DE Job, HC Whalley, EC Johnstone, SM Lawrie - Neuroimage, 2005 - Elsevier
Schizophrenia affects approximately 1% of the population and is associated with reductions
in brain volume, but when these are first evident is unknown. Magnetic resonance imaging …

A selective review of volumetric and morphometric imaging in schizophrenia

JJ Levitt, L Bobrow, D Lucia, P Srinivasan - Behavioral neurobiology of …, 2010 - Springer
Brain imaging studies have long supported that schizophrenia is a disorder of the brain,
involving many discrete and widely spread regions. Generally, studies have shown …