Introduction Adolescent idiopathic scoliosis (AIS) is a multifactorial condition with genetic
predisposing factors, and several causes have been put forward for its aetiopathogenesis …

Background: The melatonin deficiency hypothesis as a central mechanism in the
pathogenesis of adolescent idiopathic scoliosis (AIS) is certainly intriguing. However, the …

The cause of adolescent idiopathic scoliosis (AIS) in humans remains obscure and probably
multifactorial. At present, there is no proven method or test available to identify children or …

Study Design. In vitro assays were performed with bone-forming cells isolated from 41
patients with adolescent idiopathic scoliosis and 17 control patients exhibiting another type …

Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis that affects a
significant number of young teenagers, mainly females (0.2-6% of the population) …

The defect of the melatonin signaling pathway has been proposed to be one of the key
etiopathogenic factors in adolescent idiopathic scoliosis (AIS). A previous report showed that …

The correlation of serum melatonin levels and curve progression in adolescent idiopathic
scoliosis, and the effects of melatonin therapy in scoliotic patients with reduced levels of …

Melatonin deficiency has been postulated as an etiologic factors in adolescent idiopathic
scoliosis (AIS). In previous studies, melatonin was shown to regulate skeletal growth and …

Study Design Matched pairs of adolescent girls were used to compare serum melatonin
levels in adolescent patients and control subjects with idiopathic scoliosis during the day …

Presently, the genetic cause of adolescent idiopathic scoliosis (AIS), the most common form
of scoliosis, remains unclear. Among many hypotheses, the neuroendocrine hypothesis …