Exercise itself is fundamental for good health, and when practiced regularly confers a myriad
of metabolic benefits in a range of tissues. These benefits are mediated by a range of …

A growing body of evidence suggests that exercise shows pleiotropic effects on the
maintenance of systemic homeostasis through mitochondria. Dysregulation of mitochondrial …

Mitochondria are vital organelles that provide energy for muscle function. When these
organelles become dysfunctional, they produce less energy as well as excessive levels of …

Exercise is a well-known stimulus for the expansion of the mitochondrial pool within skeletal
muscle. Mitochondria have a remarkable ability to remodel their networks and can respond …

Exercise training enhances physical performance and confers health benefits, largely
through adaptations in skeletal muscle. Mitochondrial adaptation, encompassing …

Mitochondrial health is an important mediator of cellular function across a range of tissues,
and as a result contributes to whole‐body vitality in health and disease. Our understanding …

We provide an overview of groundbreaking studies that laid the foundation for our current
understanding of exercise-induced mitochondrial biogenesis and its contribution to human …

Behavioural and hereditary conditions are known to decrease mitochondrial volume and
function within skeletal muscle. This reduces endurance performance, and is manifest both …

Skeletal muscle mitochondrial content and function are regulated by a number of
specialized molecular pathways that remain to be fully defined. Although a number of …

Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …