The present and the future of degradable dendrimers and derivatives in theranostics

V Leiro, JP Garcia, H Tomás, AP Pêgo - Bioconjugate chemistry, 2015 - ACS Publications
Interest in dendrimer-based nanomedicines has been growing recently, as it is possible to
precisely manipulate the molecular weight, chemical composition, and surface functionality …

Preclinical studies of dendrimer prodrugs

C Kojima - Expert Opinion on Drug Metabolism & Toxicology, 2015 - Taylor & Francis
Introduction: Dendrimers are synthetic macromolecules with well-defined structures bearing
a wide variety of functional groups on their periphery. These groups can be used to …

Dendrimers as drug delivery systems

G Kyriazis, P Papaioannidou - Front. Pharmacol. Conference Abstract …, 2010 - frontiersin.org
Dendrimers are a unique class of repeatedly branched polymeric nanomolecules, with a
tremendous potential in applications involving imaging, diagnostics and targeted therapy. As …

Dendrimers in medicine: therapeutic concepts and pharmaceutical challenges

L Wu, M Ficker, JB Christensen… - Bioconjugate …, 2015 - ACS Publications
Dendrimers are three-dimensional macromolecular structures originating from a central core
molecule and surrounded by successive addition of branching layers (generation). These …

Multivalent dendritic architectures for theranostics

S Reichert, M Calderón, K Licha, R Haag - … Nanoparticles for Drug …, 2012 - Springer
For the past few years, molecular imaging and targeted drug delivery have been playing an
important role toward personalized medicine. In designing and fabricating of multifunctional …

Dendrimer-based nanosized MRI contrast agents

H Kobayashi, MW Brechbiel - Current pharmaceutical …, 2004 - ingentaconnect.com
Paramagnetic metals can induce T1 shortening by interaction with free water molecules.
Two metal ions, Gadolinium and Manganese, are currently available for human use …

Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging

DA Tomalia, LA Reyna, S Svenson - 2007 - portlandpress.com
Dendrimers are routinely synthesized as tuneable nanostructures that may be designed and
regulated as a function of their size, shape, surface chemistry and interior void space. They …

[HTML][HTML] Diagnostic and therapeutic applications of smart nanocomposite dendrimers

V Kumar, RK Sahoo, T Basak, T Yasmin… - Frontiers in Bioscience …, 2020 - imrpress.com
Dendrimers are three dimensional, multifunctional polymeric structures which are composed
of a core and branches emanating from these structures, resembling a tree. Here, we review …

Dendrimer‐Based Medical Nanodevices for Magnetic Resonance Imaging Applications

H Cai, M Shen, X Shi - … Drug Delivery Systems: From Theory to …, 2012 - Wiley Online Library
Magnetic resonance (MR) imaging is a powerful, noninvasive imaging technique for disease
diagnosis. Its advantages include a high spatial resolution, a nonionizing radiation source …

An overview of dendrimers and their biomedical applications

N Das, PA Sharma, A Seth… - … for Drug Delivery, 2018 - api.taylorfrancis.com
The versatility of the terminal functionality and the flexibility toward structural modification
allow a broad range of utilization of dendrimers. Since their discovery, the exploitation of …