RGC and vision loss from traumatic optic neuropathy induced by repetitive closed head trauma is dependent on timing and force of impact

RS Khan, AG Ross, P Aravand, K Dine… - … vision science & …, 2021 - tvst.arvojournals.org
Purpose: Traumatic optic neuropathy (TON) is often caused by blunt head trauma and has
no currently effective treatment. Common animal models of TON induced by surgical crush …

[HTML][HTML] A controlled impact of optic nerve as a new model of traumatic optic neuropathy in mouse

AS Ibrahim, K Elmasry, M Wan… - … & Visual Science, 2018 - jov.arvojournals.org
Purpose: Traumatic optic neuropathy (TON) is the most feared visual consequence of head
and ocular trauma in both military and civilian communities, for which standard treatment …

Traumatic optic neuropathy is associated with visual impairment, neurodegeneration, and endoplasmic reticulum stress in adolescent mice

SM Hetzer, F Guilhaume-Correa, D Day, A Bedolla… - Cells, 2021 - mdpi.com
Traumatic brain injury (TBI) results in a number of impairments, often including visual
symptoms. In some cases, visual impairments after head trauma are mediated by traumatic …

Traumatic brain injury-related optic nerve damage

J Qiu, M Boucher, G Conley, Y Li… - … of Neuropathology & …, 2022 - academic.oup.com
Vision disorders are associated with traumatic brain injury (TBI) in 20%–40% of clinical
cases and involve a diverse set of potential symptoms that can present acutely or …

[HTML][HTML] Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathy

NK Evanson, F Guilhaume-Correa, JP Herman… - PLoS …, 2018 - journals.plos.org
Adult male C57BL/6J mice have previously been reported to have motor and memory
deficits after experimental closed head traumatic brain injury (TBI), without associated gross …

Establishment of a minimally invasive distal traumatic optic neuropathy model in mice to investigate cascade reactions of retinal glial cells

B Shen, H Yu, M Zhang, J Chen, Y Zhang… - The FASEB …, 2023 - Wiley Online Library
Traumatic optic neuropathy (TON) is a complication of craniocerebral, orbital and facial
injuries, leading to irreversible vision loss. At present, there is no reliable, widely used …

A novel mouse model of traumatic optic neuropathy using external ultrasound energy to achieve focal, indirect optic nerve injury

W Tao, G Dvoriantchikova, BC Tse, S Pappas… - Scientific reports, 2017 - nature.com
Traumatic optic neuropathy (TON) is a devastating cause of permanent visual loss following
blunt injury to the head. Animal models for TON exist, but most fail to recapitulate the clinical …

Indirect traumatic optic neuropathy: modeling optic nerve injury in the context of closed head trauma

EG Burke, SM Cansler, NK Evanson - Neural Regeneration …, 2019 - journals.lww.com
Traumatic optic neuropathy: Traumatic brain injury is one of the leading causes of disability
and mortality in the United States. It impacts people of all ages and demographics …

Indirect traumatic optic neuropathy

EL Singman, N Daphalapurkar, H White… - Military Medical …, 2016 - Springer
Indirect traumatic optic neuropathy (ITON) refers to optic nerve injury resulting from impact
remote to the optic nerve. The mechanism of injury is not understood, and there are no …

Traumatic optic neuropathy: a case report

LVR OD, OD Charles Haskes - Clinical Eye and Vision Care, 1999 - Elsevier
Traumatic optic neuropathy (TON) is considered to be a true ophthalmic emergency. The
National Acute Spinal Cord Injury Study 2 (NASCIS 2) established the current treatment …