The mineralized skeleton in vertebrates protects the internal organs, helps in locomotion
and eases survival in adverse external environment. Many biological processes and …

ABSTRACT Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme
present in bone and cartilage, has important roles in the developing skeleton. We previously …

Abstract Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid metabolizing enzyme
present in the endoplasmic reticulum and plasma membranes of cells has important roles in …

PHOSPHO1 is a phosphatase highly expressed in bone. We studied its functional
involvement in mineralization through the use of novel small molecule inhibitors …

Mineralized “hard” tissues of the skeleton possess unique biomechanical properties to
support the body weight and movement and act as a source of essential minerals required …

Osteocytes produce DMP1 (dentin matrix protein 1), FGF23 (fibroblast growth factor 23) and
sclerostin. FGF23 is a phosphate-regulating hormone that links bone to kidney. DMP1 is a …

Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone
and cartilage, has been identified to be a key regulator of skeletal development. A …

The vertebrate skeleton is a hugely complex organ which performs varied and diverse
functions encompassing its action as a biomechanical and protective scaffold in conjunction …

Abstract Dentin matrix protein 1 (DMP‐1) is a key molecule in controlling osteocyte formation
and phosphate homeostasis. Based on observations that full‐length DMP‐1 is not found in …

Summary Sphingomyelin phosphodiesterase 3 (SMPD3) is a pleiotropic lipid metabolizing
enzyme involved in multiple physiological processes. A deletion mutation in the murine …