Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the
necrosis of tumors, but it has been recently identified to have additional important functions …

Tumor necrosis factor-α (TNF-α) was first isolated two decades ago as a
macrophageproduced protein that can effectively kill tumor cells. TNF-α is also an essential …

Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …

Almost two decades ago, tumor necrosis factor (TNF) was identified as a protein produced
by the immune system that played a major role in suppression of tumor cell proliferation …

Excess levels of tumor necrosis factor-α (TNF-α) have been associated with certain
autoimmune diseases. Under the rationale that elevated TNF-α levels are deleterious …

Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated
inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic …

Introduction 3. TNF-alpha cell-signaling 4. Role of TNF-alpha in inflammation 5. Role of TNF-
alpha in tumorigenesis 5.1. TNF-alpha can induce tumor initiation and promotion 5.2. Tumor …

The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …

TNF-α is a crucial pro-inflammatory and immunregulatory cytokine that is central to the
pathogenesis of various inflammatory and autoimmune conditions. A number of controlled …

Anti-Tumor Necrosis Factor (TNF) agents were the first molecular targeting drugs developed
for the treatment of rheumatoid arthritis (RA). Anti-TNF agents improve the clinical picture of …