Diabetes is a multi-faceted disorder with increasing prevalence and rising healthcare costs.
The burden of diabetes is increased because of associated complications affecting nearly all …

The opioid growth factor (OGF)–OGF receptor (OGFr) pathway is present in the ocular
surface and functions to maintain homeostasis of the epithelium. The OGF–OGFr pathway …

Background: Diabetes is a worldwide epidemic with more than 550 million individuals
expected to be diagnosed with the disease by 2030. Complications associated with diabetes …

Diabetes often presents with ocular surface complications including dry eye, keratopathy,
and altered sensitivity, along with systemic disorders. A common theme associated with …

The Opioid Growth Regulatory System consists of opioid growth factor (OGF),[Met 5]-
enkephalin, and its unique receptor (OGFr). OGF inhibits cell division when bound to OGFr …

Approximately 4.5 million women in the United States exhibit diabetes‑associated ocular
complications. The time course and magnitude of these complications, and their association …

Diabetes is a widespread autoimmune disorder that affects nearly 10% of the adult
population in the United States. In addition to the primary disease, there are numerous …

Ocular surface complications occur in more than 50% of individuals diagnosed with
diabetes. The financial and health-related burden of diabetes is increasing annually …

Background: Diabetes is a chronic disorder that affects more than 500 million individuals
worldwide. It is a life-long disease with complications that attack nearly all other systems …

The opioid growth factor (OGF)–OGF receptors (OGFr) axis plays an important role in the
homeostasis and re-epithelialization of the mammalian cornea. This tonically active growth …