Co-cultures allow for the study of cell–cell interactions between different eukaryotic species
or with bacteria. Such an approach has enabled researchers to more closely mimic complex …

Oral mucosa is the target tissue for many microorganisms involved in periodontitis and other
infectious diseases affecting the oral cavity. Three-dimensional (3D) in vitro and ex vivo oral …

Over the past century, numerous studies have used oral biofilm models to investigate growth
kinetics, biofilm formation, structure and composition, antimicrobial susceptibility and host …

More than 700 microbial species inhabit the complex environment of the oral cavity. For
years microorganisms have been studied in pure cultures, a highly artificial situation …

There are few high-throughput in vitro systems which facilitate the development of multi-
species biofilms that contain numerous species commonly detected within in vivo oral …

Numerous in vitro biofilm model systems are available to study oral biofilms. Over the past
several decades, increased understanding of oral biology and advances in technology have …

The human oral cavity is host to a diverse microbiota. Much of what is known about the
behaviour of oral microbes derives from studies of individual or several cultivated species …

Oral biofilms are three‐dimensional (3D) complex entities initiating dental diseases and
have been evaluated extensively in the scientific literature using several biofilm models and …

Numerous studies on oral biofilms have been performed in vitro, although it is difficult to
mimic the oral environment. Here we used an in situ model to conduct a quantitative …

The aim of this study was to (i) design, develop and validate a practical and physiologically
relevant reconstituted in vitro oral mucosa tissue model and (ii) to assess its applicability in …