At the metal–metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin
AM Traynor, RA Owens, CM Coughlin… - …, 2021 - microbiologyresearch.org
Cryptic links between apparently unrelated metabolic systems represent potential new drug
targets in fungi. Evidence of such a link between zinc and gliotoxin (GT) biosynthesis in …
targets in fungi. Evidence of such a link between zinc and gliotoxin (GT) biosynthesis in …
Systems impact of zinc chelation by the epipolythiodioxopiperazine dithiol gliotoxin in Aspergillus fumigatus: a new direction in natural product functionality
The non-ribosomal peptide gliotoxin, which autoinduces its own biosynthesis, has potent
anti-fungal activity, especially in the combined absence of the gliotoxin oxidoreductase GliT …
anti-fungal activity, especially in the combined absence of the gliotoxin oxidoreductase GliT …
Interplay between gliotoxin resistance, secretion, and the methyl/methionine cycle in Aspergillus fumigatus
Mechanistic studies on gliotoxin biosynthesis and self-protection in Aspergillus fumigatus,
both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of …
both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of …
The Role of Zinc in Gliotoxin Biosynthesis of Aspergillus fumigatus
H Seo, S Kang, YS Park, CW Yun - International journal of molecular …, 2019 - mdpi.com
Zinc performs diverse physiological functions, and virtually all living organisms require zinc
as an essential trace element. To identify the detailed function of zinc in fungal …
as an essential trace element. To identify the detailed function of zinc in fungal …
Dysregulated gliotoxin biosynthesis attenuates the production of unrelated biosynthetic gene cluster-encoded metabolites in Aspergillus fumigatus
Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …
Fungal Zinc Homeostasis and Its Potential as an Antifungal Target: A Focus on the Human Pathogen Aspergillus fumigatus
P Zhai, Y Chai, L Lu - Microorganisms, 2022 - mdpi.com
Aspergillus fumigatus is an opportunistic airborne fungus that causes severe invasive
aspergillosis in immunocompromised patients. Zinc is an essential micronutrient for the …
aspergillosis in immunocompromised patients. Zinc is an essential micronutrient for the …
Regulation of gliotoxin biosynthesis and protection in Aspergillus species
PA de Castro, AC Colabardini, M Moraes… - PLoS …, 2022 - journals.plos.org
Aspergillus fumigatus causes a range of human and animal diseases collectively known as
aspergillosis. A. fumigatus possesses and expresses a range of genetic determinants of …
aspergillosis. A. fumigatus possesses and expresses a range of genetic determinants of …
The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence
Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-
modulatory molecules, including secondary metabolites (SMs), which contribute to …
modulatory molecules, including secondary metabolites (SMs), which contribute to …
The interplay between iron and zinc metabolism in Aspergillus fumigatus
S Yasmin, B Abt, M Schrettl, TAA Moussa… - Fungal Genetics and …, 2009 - Elsevier
Zinc plays a critical role in a diverse array of biochemical processes. However, excess of
zinc is deleterious to cells. Therefore, cells require finely tuned homeostatic mechanisms to …
zinc is deleterious to cells. Therefore, cells require finely tuned homeostatic mechanisms to …
Proteomic analyses reveal the key roles of BrlA and AbaA in biogenesis of gliotoxin in Aspergillus fumigatus
The opportunistic human pathogenic fungus Aspergillus fumigatus primarily reproduces by
forming a large number of asexual spores (conidia). Sequential activation of the central …
forming a large number of asexual spores (conidia). Sequential activation of the central …
相关搜索
- aspergillus fumigatus zinc homeostasis
- aspergillus fumigatus biogenesis of gliotoxin
- gliotoxin biosynthesis aspergillus species
- aspergillus fumigatus antifungal target
- aspergillus fumigatus proteomic analyses
- aspergillus fumigatus transcription factor
- aspergillus fumigatus brla and abaa
- aspergillus fumigatus zinc metabolism
- aspergillus fumigatus zinc starvation
- aspergillus fumigatus zinc chelation