Cryptic links between apparently unrelated metabolic systems represent potential new drug
targets in fungi. Evidence of such a link between zinc and gliotoxin (GT) biosynthesis in …

Gliotoxin (GT) biosynthesis in fungi is encoded by the gli biosynthetic gene cluster. While GT
addition autoinduces biosynthesis, Zn 2+ has been shown to attenuate cluster activity, and it …

The non-ribosomal peptide gliotoxin, which autoinduces its own biosynthesis, has potent
anti-fungal activity, especially in the combined absence of the gliotoxin oxidoreductase GliT …

Mechanistic studies on gliotoxin biosynthesis and self-protection in Aspergillus fumigatus,
both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of …

Zinc performs diverse physiological functions, and virtually all living organisms require zinc
as an essential trace element. To identify the detailed function of zinc in fungal …

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …

Aspergillus fumigatus causes a range of human and animal diseases collectively known as
aspergillosis. A. fumigatus possesses and expresses a range of genetic determinants of …

Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-
modulatory molecules, including secondary metabolites (SMs), which contribute to …

Zinc plays a critical role in a diverse array of biochemical processes. However, excess of
zinc is deleterious to cells. Therefore, cells require finely tuned homeostatic mechanisms to …

The opportunistic human pathogenic fungus Aspergillus fumigatus primarily reproduces by
forming a large number of asexual spores (conidia). Sequential activation of the central …