Background Aspergillus fumigatus has to cope with a combination of several stress types
while colonizing the human body. A functional interplay between these different stress …

Aspergillus fumigatus is a major opportunistic human pathogen. Multiple traits contribute to
A. fumigatus pathogenicity, including its ability to produce specific secondary metabolites …

As recently described, fungal secondary metabolism activates during infection in response
to a hostile host environment. Gliotoxin and bis (methylthio) gliotoxin are two recognized …

Fungal infections are of major relevance due to the increased numbers of
immunocompromised patients, frequently delayed diagnosis, and limited therapeutics. To …

To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization
to ensure sufficient supply and to avoid toxic excess of this essential trace element. As …

Gliotoxin is an important virulence factor of Aspergillus fumigatus. Although GliA putatively
belongs to the major facilitator superfamily in the gliotoxin biosynthesis cluster, its roles …

Aspergillus fumigatus is the most common causative agent of mold diseases in humans,
giving rise to life-threatening infections in immunocompromised individuals. One of its …

Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

Gliotoxin (1), the infamous representative of the group of epipolythiodioxopiperazines
(ETPs), is a virulence factor of the human pathogenic fungus Aspergillus fumigatus. The …

Siderophores play an important role in fungal virulence, serving as trackers for in vivo
imaging and as biomarkers of fungal infections. However, siderophore uptake is only …