Vasa recta pericyte density is negatively associated with vascular congestion in the renal medulla following ischemia reperfusion in rats
GR Crislip, PM O'Connor, Q Wei… - American Journal of …, 2017 - journals.physiology.org
Recent evidence suggests that a greater density of pericytes in renal cadaveric allografts is
associated with better recovery following transplant. The physiological mechanism (s) …
associated with better recovery following transplant. The physiological mechanism (s) …
[HTML][HTML] Inflammatory mediators act at renal pericytes to elicit contraction of vasa recta and reduce pericyte density along the kidney medullary vascular network
RJ Lilley, KD Taylor, SSP Wildman… - Frontiers in …, 2023 - frontiersin.org
Introduction: Regardless of initiating cause, renal injury promotes a potent pro-inflammatory
environment in the outer medulla and a concomitant sustained decrease in medullary blood …
environment in the outer medulla and a concomitant sustained decrease in medullary blood …
Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia
F Freitas, D Attwell - Elife, 2022 - elifesciences.org
Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …
Exogenous pericyte delivery protects the mouse kidney from chronic ischemic injury
T Song, XY Zhu, A Eirin, Y Jiang… - American Journal …, 2022 - journals.physiology.org
Pericytes are considered reparative mesenchymal stem cell-like cells, but their ability to
ameliorate chronic ischemic kidney injury is unknown. We hypothesized that pericytes would …
ameliorate chronic ischemic kidney injury is unknown. We hypothesized that pericytes would …
Preservation of peritubular capillary endothelial integrity and increasing pericytes may be critical to recovery from postischemic acute kidney injury
O Kwon, SM Hong, TA Sutton… - American Journal of …, 2008 - journals.physiology.org
Decreased renal blood flow following an ischemic insult contributes to a reduction in
glomerular filtration. However, little is known about the underlying cellular or subcellular …
glomerular filtration. However, little is known about the underlying cellular or subcellular …
[HTML][HTML] Pathophysiological and molecular mechanisms involved in renal congestion in a novel rat model
S Shimada, T Hirose, C Takahashi, E Sato… - Scientific reports, 2018 - nature.com
Increased central venous pressure in congestive heart failure causes renal dysfunction;
however, the underlying mechanisms are unclear. We created a rat renal congestion model …
however, the underlying mechanisms are unclear. We created a rat renal congestion model …
Maintenance of vascular integrity by pericytes is essential for normal kidney function
Pericytes are tissue-resident mesenchymal progenitor cells anatomically associated with the
vasculature that have been shown to participate in tissue regeneration. Here, we tested the …
vasculature that have been shown to participate in tissue regeneration. Here, we tested the …
Renal pericytes: regulators of medullary blood flow
TM Kennedy‐Lydon, C Crawford… - Acta …, 2013 - Wiley Online Library
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function.
Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from …
Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from …
Renal ischemia-reperfusion induces a dysbalance of angiopoietins, accompanied by proliferation of pericytes and fibrosis
M Khairoun, P van der Pol… - American Journal …, 2013 - journals.physiology.org
Endothelial cells (ECs) are highly susceptible to hypoxia and easily affected upon ischemia-
reperfusion (I/R) during renal transplantation. Pericytes and angiopoeitins play important …
reperfusion (I/R) during renal transplantation. Pericytes and angiopoeitins play important …
Pericyte regulation of renal medullary blood flow
TL Pallone, EP Silldorff - Experimental nephrology, 2001 - karger.com
Pericytes are contractile smooth muscle-like cells that surround descending vasa recta
(DVR) and provide their capability for vasomotion. The importance of the medullary pericyte …
(DVR) and provide their capability for vasomotion. The importance of the medullary pericyte …