Recent evidence suggests that a greater density of pericytes in renal cadaveric allografts is
associated with better recovery following transplant. The physiological mechanism (s) …

Introduction: Regardless of initiating cause, renal injury promotes a potent pro-inflammatory
environment in the outer medulla and a concomitant sustained decrease in medullary blood …

Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …

Pericytes are considered reparative mesenchymal stem cell-like cells, but their ability to
ameliorate chronic ischemic kidney injury is unknown. We hypothesized that pericytes would …

Decreased renal blood flow following an ischemic insult contributes to a reduction in
glomerular filtration. However, little is known about the underlying cellular or subcellular …

Increased central venous pressure in congestive heart failure causes renal dysfunction;
however, the underlying mechanisms are unclear. We created a rat renal congestion model …

Pericytes are tissue-resident mesenchymal progenitor cells anatomically associated with the
vasculature that have been shown to participate in tissue regeneration. Here, we tested the …

Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function.
Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from …

Endothelial cells (ECs) are highly susceptible to hypoxia and easily affected upon ischemia-
reperfusion (I/R) during renal transplantation. Pericytes and angiopoeitins play important …

Pericytes are contractile smooth muscle-like cells that surround descending vasa recta
(DVR) and provide their capability for vasomotion. The importance of the medullary pericyte …