Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity–a nationwide cross …

RR Putri, T Casswall, E Hagman - BMC pediatrics, 2021 - Springer
Background Childhood obesity increases the risk of non-alcoholic fatty liver disease marked
by elevated alanine aminotransferase (ALT). This study investigated the prevalence of …

Prevalence of elevated liver enzymes and comorbidities in children and adolescents with overweight and obesity

C Hartman, HS Rennert, G Rennert… - Acta …, 2021 - Wiley Online Library
Aim We investigated the prevalence of elevated liver aminotransferases (ALT) and
additional comorbidities in a large cohort of Israeli children and adolescents with overweight …

Association of raised liver transaminases with physical inactivity, increased waist–hip ratio, and other metabolic morbidities in severely obese children

YS Lee, BLK Kek, LKS Poh, SM Saw… - Journal of pediatric …, 2008 - journals.lww.com
Objective: To identify factors associated with raised alanine transaminase, aspartate
transaminase, and γ-glutaryl transferase in severely obese children Patients and Methods …

Association of elevated serum alanine aminotransferase with metabolic factors in obese children: sex-related analysis

P Di Bonito, E Sanguigno, T Di Fraia, C Forziato… - Metabolism, 2009 - Elsevier
Alanine aminotransferase (ALT) elevations are considered a surrogate marker of
nonalcoholic liver disease and predict later development of diabetes and metabolic …

Prevalence of Elevated ALT in Adolescents in the US 2011–2018

AK Mischel, Z Liao, F Cao, W Dunn, JC Lo… - Journal of Pediatric …, 2023 - journals.lww.com
Objective: The objective of this study is to characterize suspected nonalcoholic fatty liver
disease (NAFLD) using elevated alanine aminotransferase (ALT) in a diverse and nationally …

Elevated transaminases potentiate the risk for emerging dysglycemia in children with overweight and obesity

F Koutny, R Stein, W Kiess, D Weghuber… - Pediatric …, 2021 - Wiley Online Library
Background There is evidence that nonalcoholic fatty liver disease (NAFLD) increases the
risk for dysglycemia in children in cross‐sectional studies. However, the extent to which …

Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents

H Riekki, L Aitokari, L Kivelä, S Lahti… - Frontiers in …, 2023 - frontiersin.org
Introduction Data on the prevalence of pediatric fatty liver disease remain limited, partly due
to challenges in diagnosis. A novel concept of metabolic-associated fatty liver disease …

Alanine aminotransferase cutoffs for the pediatric fatty liver disease: Major impact of the reference population

L Aitokari, S Lahti, L Kivelä, H Riekki… - Journal of Pediatric …, 2024 - Wiley Online Library
Abstract Objectives and Study The often‐recommended alanine aminotransferase (ALT)
cutoffs (girls 21 U/l, boys 25 U/l) are based on a NHANES cohort. A novel concept of …

Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents: 2001-2014

JW Kim, KJ Lee, HR Yang, JY Chang, JS Moon… - BMC Public Health, 2018 - Springer
Background An elevated alanine aminotransferase (ALT) level is a surrogate marker of non-
alcoholic fatty liver disease (NAFLD), the most common liver disorder in adolescents. The …

Gender differences in healthy ranges for serum alanine aminotransferase levels in adolescence

H Poustchi, J George, S Esmaili, F Esna-Ashari… - PloS one, 2011 - journals.plos.org
Background & Aims There is a worldwide epidemic of obesity among adolescents who
subsequently are at increased risk for the development of non alcoholic fatty liver disease …