Does chronic obstructive pulmonary disease originate from different cell types?

Y Tesfaigzi, JL Curtis, I Petrache… - American journal of …, 2023 - atsjournals.org
The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current
approaches to define distinct disease phenotypes are lacking. In addition to clinical …

Early endotyping: a chance for intervention in chronic obstructive pulmonary disease

H Petersen, R Vazquez Guillamet, P Meek… - American journal of …, 2018 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung
pathologies, but subphenotyping the various disease subtypes has been difficult. One …

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

Applying functional genomics to chronic obstructive pulmonary disease

EK Silverman - Annals of the American Thoracic Society, 2018 - atsjournals.org
Genome-wide association studies (GWAS) have identified more than 20 genomic regions
associated with chronic obstructive pulmonary disease (COPD) susceptibility. However, the …

De novo discovery of traits co-occurring with chronic obstructive pulmonary disease

E Golovina, T Fadason, RK Jaros… - Life Science …, 2023 - life-science-alliance.org
Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of chronic lung
conditions. Genome-wide association studies have identified single-nucleotide …

Omics and the search for blood biomarkers in chronic obstructive pulmonary disease. Insights from COPDGene

EA Regan, CP Hersh, PJ Castaldi… - American journal of …, 2019 - atsjournals.org
There is an unmet need for blood biomarkers in diagnosis and prognosis of chronic
obstructive pulmonary disease (COPD). The search for these biomarkers has been …

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

X Chen, X Xu, F Xiao - Frontiers of medicine, 2013 - Springer
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity
and mortality throughout the world and is mainly characterized by persistent airflow …

Expression profiling suggests loss of surface integrity and failure of regenerative repair as major driving forces for chronic obstructive pulmonary disease progression

E Samaha, K Vierlinger, W Weinhappel… - American Journal of …, 2021 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) poses a major risk for public health, yet
remarkably little is known about its detailed pathophysiology. Definition of COPD as …

Genetic advances in chronic obstructive pulmonary disease. Insights from COPDGene

MF Ragland, CJ Benway, SM Lutz… - American journal of …, 2019 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …

Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung

K Steiling, ME Lenburg, A Spira - Annals of the American Thoracic …, 2013 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a clinically heterogeneous disease
composed of variable degrees of airflow obstruction, emphysematous destruction, and small …