Does chronic obstructive pulmonary disease originate from different cell types?
The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current
approaches to define distinct disease phenotypes are lacking. In addition to clinical …
approaches to define distinct disease phenotypes are lacking. In addition to clinical …
Early endotyping: a chance for intervention in chronic obstructive pulmonary disease
H Petersen, R Vazquez Guillamet, P Meek… - American journal of …, 2018 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung
pathologies, but subphenotyping the various disease subtypes has been difficult. One …
pathologies, but subphenotyping the various disease subtypes has been difficult. One …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
Applying functional genomics to chronic obstructive pulmonary disease
EK Silverman - Annals of the American Thoracic Society, 2018 - atsjournals.org
Genome-wide association studies (GWAS) have identified more than 20 genomic regions
associated with chronic obstructive pulmonary disease (COPD) susceptibility. However, the …
associated with chronic obstructive pulmonary disease (COPD) susceptibility. However, the …
De novo discovery of traits co-occurring with chronic obstructive pulmonary disease
E Golovina, T Fadason, RK Jaros… - Life Science …, 2023 - life-science-alliance.org
Chronic obstructive pulmonary disease (COPD) is a heterogeneous group of chronic lung
conditions. Genome-wide association studies have identified single-nucleotide …
conditions. Genome-wide association studies have identified single-nucleotide …
Omics and the search for blood biomarkers in chronic obstructive pulmonary disease. Insights from COPDGene
There is an unmet need for blood biomarkers in diagnosis and prognosis of chronic
obstructive pulmonary disease (COPD). The search for these biomarkers has been …
obstructive pulmonary disease (COPD). The search for these biomarkers has been …
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
X Chen, X Xu, F Xiao - Frontiers of medicine, 2013 - Springer
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity
and mortality throughout the world and is mainly characterized by persistent airflow …
and mortality throughout the world and is mainly characterized by persistent airflow …
Expression profiling suggests loss of surface integrity and failure of regenerative repair as major driving forces for chronic obstructive pulmonary disease progression
E Samaha, K Vierlinger, W Weinhappel… - American Journal of …, 2021 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) poses a major risk for public health, yet
remarkably little is known about its detailed pathophysiology. Definition of COPD as …
remarkably little is known about its detailed pathophysiology. Definition of COPD as …
Genetic advances in chronic obstructive pulmonary disease. Insights from COPDGene
Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …
is influenced by both genetic and environmental factors. For many years, knowledge of the …
Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung
K Steiling, ME Lenburg, A Spira - Annals of the American Thoracic …, 2013 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a clinically heterogeneous disease
composed of variable degrees of airflow obstruction, emphysematous destruction, and small …
composed of variable degrees of airflow obstruction, emphysematous destruction, and small …