HBZ and its roles in HTLV-1 oncogenesis

T Zhao, M Matsuoka - Frontiers in microbiology, 2012 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus
strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ) …

Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis

G Ma, J Yasunaga, M Matsuoka - Retrovirology, 2016 - Springer
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the
development of adult T-cell leukemia (ATL). Although HTLV-1 harbors an oncogene, tax …

HTLV-1 bZIP factor: the key viral gene for pathogenesis

M Matsuoka, JM Mesnard - Retrovirology, 2020 - Springer
Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL)
and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in …

HTLV-1 alters T cells for viral persistence and transmission

A Tanaka, M Matsuoka - Frontiers in microbiology, 2018 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus to be discovered as a
causative agent of adult T-cell leukemia-lymphoma (ATL) and chronic inflammatory …

Localization, quantification and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL

GU Raval, C Bidoia, G Forlani, G Tosi, A Gessain… - Retrovirology, 2015 - Springer
Background Human T cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of a
severe form of neoplasia designated Adult T cell Leukaemia (ATL). It is widely accepted that …

The HBZ gene, a key player in HTLV-1 pathogenesis

M Matsuoka, PL Green - Retrovirology, 2009 - Springer
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL)
and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic …

Human T-Cell Leukemia Virus Type 1 Oncogenesis between Active Expression and Latency: A Possible Source for the Development of Therapeutic Targets

F Marino-Merlo, S Grelli, A Mastino, M Lai… - International Journal of …, 2023 - mdpi.com
The human T-cell leukemia virus type 1 (HTLV-1) is the only known human oncogenic
retrovirus. HTLV-1 can cause a type of cancer called adult T-cell leukemia/lymphoma (ATL) …

The role of HBZ in HTLV-1-induced oncogenesis

T Zhao - Viruses, 2016 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and
chronic inflammatory diseases. HTLV-1 bZIP factor (HBZ) is transcribed as an antisense …

HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells

G Ma, J Yasunaga, J Fan, S Yanagawa, M Matsuoka - Oncogene, 2013 - nature.com
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia
(ATL). 1–5 HTLV-1 Tax is an important viral transactivator, and has been thought to have a …

HTLV-1 bZIP factor gene: Its roles in HTLV-1 pathogenesis

M Matsuoka - Molecular aspects of medicine, 2010 - Elsevier
The HTLV-1 bZIP factor (HBZ) gene is transcribed as an anti-sense transcript of HTLV-1 from
the 3′ long terminal repeat (LTR). Recent studies showed that the HBZ gene was …