Objectives To determine the impact of pretreatment low-abundance HIV-1 drug-resistant
variants (LA-DRVs) on virological failure (VF) among HIV-1/TB-co-infected individuals …

Objectives To assess the impact of pretreatment low-abundance HIV drug-resistant variants
(LA-DRVs) on virological outcomes among ART-naive HIV-1-infected Chinese people who …

Abstract Background Minor (ie,< 20% prevalence) drug-resistant human immunodeficiency
virus (HIV) variants may go undetected, yet be clinically important Objectives To compare …

Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …

Abstract Background In sub-Saharan Africa, detecting resistance-associated mutations
(RAMs) at failure of first-line ART with two NRTIs plus an NNRTI predicts improved …

Background Effective ART is crucial for combating the HIV pandemic. Clinically, plasma viral
load monitoring to achieve virological suppression is the guide for an optimal ART. The …

Background The association between low-frequency human immunodeficiency virus type 1
(HIV-1) drug resistance mutations (DRMs) and treatment failure (TF) is controversial. We …

Objectives It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect
the virological outcomes of first-line NNRTI-containing ART. Methods This Europe-wide case …

Virological suppression rates achieved with the new antiretroviral drugs in patients with
virological failure and resistance to multiple drug classes are nearly matching the rates seen …

Objectives The presence of minority transmitted drug resistance mutations was assessed
using ultra-deep sequencing and correlated with disease progression among recently HIV-1 …