The lipid bilayer's integrity is essential for cell function as it acts as the primary barrier
against external molecules like drugs and peptides, which can alter the bilayer's physical …

Cell membranes are fundamental for cellular function as they protect the cell and control
passage in and out of the cell. Despite their clear significance, cell membranes are often …

It remains a challenge to predict whether a new drug candidate will have undesirable side
effects. Many biologically active molecules, including drugs and drug-leads, are amphiphiles …

The enzyme phospholipase A2 (PLA 2) is a protein family that hydrolyzes the Sn-2 fatty tail
of membrane phospholipids. Various studies show that regulation of PLA 2 activity is related …

Membrane-enveloped viruses are responsible for most viral pandemics in history, and more
effort is needed to advance broadly applicable countermeasures to mitigate the impact of …

The unassisted permeation process of β-blocker drugs (alprenolol, atenolol, pindolol) and
steroid hormones (progesterone, testosterone) through a lipid membrane is simulated by a …

Enfuvirtide and T-1249 are two potent HIV-1 fusion inhibitor peptides. Recent studies
indicate that lipids play an important role in the mode of action of those bioactive molecules …

Lipids self-assemble into lipid bilayers, which divide bodily tissues into cells and into
functionally specified compartments. Imbalances in the lipid composition and metabolism …

Extensive research has been conducted on biomimetic interfaces mimicking the complex
and diverse microenvironment of cell membranes to gain insights into bioactive compound …

Though vesicles are recognized as effective drug carriers and functionalized with polymers,
targeting ligands, imaging agents, and antibodies for drug delivery applications, there is …