pH-dependent formation of lipid heterogeneities controls surface topography and binding reactivity in functionalized bilayers

GB Kempegowda, S Karve, A Bandekar, A Adhikari… - Langmuir, 2009 - ACS Publications
During direct cell-to-cell communication, lipids on the extracellular side of plasma
membranes reorganize, and membrane-associated communication-related molecules …

Drug-lipid membrane interaction mechanisms revealed through molecular simulations

O Cramariuc, T Rog, I Vattulainen - Current Physical Chemistry, 2012 - ingentaconnect.com
Traditionally it has been assumed that drugs interact with membranes via specific binding
with membrane proteins. This view has recently been questioned as more and more data …

[HTML][HTML] Mimicking the mammalian plasma membrane: An overview of lipid membrane models for biophysical studies

A Luchini, G Vitiello - Biomimetics, 2020 - mdpi.com
Cell membranes are very complex biological systems including a large variety of lipids and
proteins. Therefore, they are difficult to extract and directly investigate with biophysical …

Experimental and Computational Approaches to Study Membranes and Lipid–-Protein Interactions

A CHATTOPADHYAY - Computational Biophysics of Membrane …, 2016 - books.google.com
The cellular membrane is a complex combination of lipids and proteins, whose composition
is organelle-, tissue-and age-dependent. 1–4 Membrane proteins are implicated in a wide …

[HTML][HTML] Suspended lipid bilayer: a versatile platform for nextgen drug discovery and biomedical applications

S Ramakrishnan, JS Weerakkody - Accounts of Materials …, 2022 - ACS Publications
Lipid membranes play vital roles in regulating cellular processes, including the first line of
defense against infection, and subcellular compartmentalization and provide a natural …

A tunable lipid bilayer native MS platform for direct determination of hierarchical organization of membrane proteins and lipids at the membrane

A Panda, F Giska, C Brown, J Coleman, JE Rothman… - Biophysical …, 2022 - cell.com
312a Tuesday, February 22, 2022 of their masses, oligomeric states, number of
transmembrane helices, as well as the target physiological membranes together establishes …

Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes

W Kopeć, J Telenius, H Khandelia - The FEBS journal, 2013 - Wiley Online Library
Several small drugs and medicinal plant extracts, such as the Indian spice extract curcumin,
have a wide range of useful pharmacological properties that cannot be ascribed to binding …

Measuring remodeling of the lipid environment surrounding membrane proteins with lipid exchange and native mass spectrometry

G Zhang, JE Keener, MT Marty - Analytical chemistry, 2020 - ACS Publications
Due to their crucial biochemical roles, membrane proteins are important drug targets.
Although it is clear that lipids can influence membrane protein function, the chemistry of lipid …

Predicting Drug Toxicity: Early Detection of Likely Failures in Drug Development

RL Sanford, W Chao, J Chiaravalli-Giganti, A Luz… - Biophysical …, 2015 - cell.com
It remains a challenge to predict whether or not a new drug candidate will have undesirable
side-effects in the clinic. Many biologically active molecules, including drugs and drug-leads …

Lipid–protein interactions in plasma membrane organization and function

T Sych, KR Levental, E Sezgin - Annual review of biophysics, 2022 - annualreviews.org
Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …