pH-dependent formation of lipid heterogeneities controls surface topography and binding reactivity in functionalized bilayers
GB Kempegowda, S Karve, A Bandekar, A Adhikari… - Langmuir, 2009 - ACS Publications
During direct cell-to-cell communication, lipids on the extracellular side of plasma
membranes reorganize, and membrane-associated communication-related molecules …
membranes reorganize, and membrane-associated communication-related molecules …
Drug-lipid membrane interaction mechanisms revealed through molecular simulations
O Cramariuc, T Rog, I Vattulainen - Current Physical Chemistry, 2012 - ingentaconnect.com
Traditionally it has been assumed that drugs interact with membranes via specific binding
with membrane proteins. This view has recently been questioned as more and more data …
with membrane proteins. This view has recently been questioned as more and more data …
[HTML][HTML] Mimicking the mammalian plasma membrane: An overview of lipid membrane models for biophysical studies
A Luchini, G Vitiello - Biomimetics, 2020 - mdpi.com
Cell membranes are very complex biological systems including a large variety of lipids and
proteins. Therefore, they are difficult to extract and directly investigate with biophysical …
proteins. Therefore, they are difficult to extract and directly investigate with biophysical …
Experimental and Computational Approaches to Study Membranes and Lipid–-Protein Interactions
A CHATTOPADHYAY - Computational Biophysics of Membrane …, 2016 - books.google.com
The cellular membrane is a complex combination of lipids and proteins, whose composition
is organelle-, tissue-and age-dependent. 1–4 Membrane proteins are implicated in a wide …
is organelle-, tissue-and age-dependent. 1–4 Membrane proteins are implicated in a wide …
[HTML][HTML] Suspended lipid bilayer: a versatile platform for nextgen drug discovery and biomedical applications
S Ramakrishnan, JS Weerakkody - Accounts of Materials …, 2022 - ACS Publications
Lipid membranes play vital roles in regulating cellular processes, including the first line of
defense against infection, and subcellular compartmentalization and provide a natural …
defense against infection, and subcellular compartmentalization and provide a natural …
A tunable lipid bilayer native MS platform for direct determination of hierarchical organization of membrane proteins and lipids at the membrane
312a Tuesday, February 22, 2022 of their masses, oligomeric states, number of
transmembrane helices, as well as the target physiological membranes together establishes …
transmembrane helices, as well as the target physiological membranes together establishes …
Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes
Several small drugs and medicinal plant extracts, such as the Indian spice extract curcumin,
have a wide range of useful pharmacological properties that cannot be ascribed to binding …
have a wide range of useful pharmacological properties that cannot be ascribed to binding …
Measuring remodeling of the lipid environment surrounding membrane proteins with lipid exchange and native mass spectrometry
Due to their crucial biochemical roles, membrane proteins are important drug targets.
Although it is clear that lipids can influence membrane protein function, the chemistry of lipid …
Although it is clear that lipids can influence membrane protein function, the chemistry of lipid …
Predicting Drug Toxicity: Early Detection of Likely Failures in Drug Development
RL Sanford, W Chao, J Chiaravalli-Giganti, A Luz… - Biophysical …, 2015 - cell.com
It remains a challenge to predict whether or not a new drug candidate will have undesirable
side-effects in the clinic. Many biologically active molecules, including drugs and drug-leads …
side-effects in the clinic. Many biologically active molecules, including drugs and drug-leads …
Lipid–protein interactions in plasma membrane organization and function
Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …