Background Cross-presentation by dendritic cells (DCs) is a crucial prerequisite for effective
priming of cytotoxic T-cell responses against bacterial, viral and tumor antigens; however …

Dendritic cells (DCs) initiate primary immune responses by presenting pathogen-derived
antigens in association with major histocompatibility Class II molecules (MHC II) to T cells. In …

For the initiation of adaptive immune responses, dendritic cells present antigenic peptides in
association with major histocompatibility complex class II (MHCII) to naïve CD4+ T …

Immature dendritic cells efficiently capture exogenous antigens in peripheral tissues. In an
inflammatory environment, dendritic cells are activated and become highly competent …

Highlights•Dendritic cells internalize exogenous antigens for cross-presentation on MHC
I.•MHC I cross-presentation allows immune surveillance of viral infection and …

Adaptation of the endoplasmic reticulum (ER) pathway for MHC class I (MHC-I) presentation
in dendritic cells enables cross-presentation of peptides derived from phagocytosed …

Major histocompatibility complex (MHC) class II (MHCII) is constitutively expressed by
immature dendritic cells (DC), but has a short half‐life as a consequence of its transport to …

Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display
peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells. Like …

Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is
involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and …

Dendritic cells (DCs) express major histocompatibility complex class II (MHC II) to present
peptide antigens to T cells. In immature DCs, which bear low cell surface levels of MHC II …