BACKGROUND Although the subject of intensive study, the genetic influences responsible
for familial clustering of prostate cancer remain largely unidentified. Genome‐wide scans for …

Prostate cancer is one of the most common cancers among men and has long been
recognized to occur in familial clusters. Brothers and sons of affected men have a twofold to …

BACKGROUND Prostate cancer linkage studies have been used to localize rare and
presumably highly penetrant cancer susceptibility genes. Underlying genetic heterogeneity …

Evidence of the existence of major prostate cancer (PC)–susceptibility genes has been
provided by multiple segregation analyses. Although genomewide screens have been …

Background: Prostate cancer represents a substantial public health burden worldwide. It is
the second leading cause of cancer death among men in the United States. A family history …

Results from over a dozen prostate cancer susceptibility genome-wide scans,
encompassing some 1,500 hereditary prostate cancer families, indicate that prostate cancer …

In 2006, f234, 460 men in the US will be diagnosed with prostate cancer, and> 27,000
deaths will be attributed to the disease (1). There is substantial phenotypic variability among …

Abstract BACKGROUND The African American Hereditary Prostate Cancer (AAHPC) Study
was designed to recruit families with early‐onset disease fulfilling criteria of≥ 4 affected …

BACKGROUND Prostate cancer is a heterogeneous disease, both genetically and
phenotypically. Linkage studies attempting to map genes for hereditary prostate cancer …

BACKGROUND Previous linkage studies have suggested prostate cancer susceptibility
genes located on chromosomes 1, 20, and X. Several putative prostate cancer candidate …