Although most pituitary adenomas behave in a purely benign fashion, microscopic invasion
of the subjacent dura is very common, and clinically overt infiltration of the surrounding dura …

Although almost all pituitary tumors are benign adenomas, a surprisingly large number of
these tumors invade tissues outside of the pituitary gland. Such invasion, by itself, is not …

Invasive adenomas show pathologic or radiological signs of invasion to the cavernous or
sphenoid sinuses, bone, or nasal mucosa. WHO classification categorizes pituitary …

Many factors influence the proliferation of pituitary adenomas: angiogenesis, apoptosis,
growth factors, oncogenes, tumor suppressor genes, and hormone receptors. These …

Pituitary adenomas comprise approx 10% of all intracranial tumors. Taking their origin in the
anterior lobe, most grow in a slow, expansible manner and are composed of cytologically …

✓ Pituitary adenomas may remain intrasellar or infiltrate dura and bone. Invasive adenomas
are not considered to be malignant; in biological behavior they are between non-infiltrative …

Pituitary adenomas originating in adenohypophysial cells represent the most common
neoplasms of the sella turcica. The pathologist's goal is the optimal diagnosis and …

Pituitary adenomas are common intracranial tumors that are mainly considered as benign.
Rarely, these tumors can exhibit an aggressive behavior, characterized by gross invasion of …

✓ The immunohistological detection of a proliferation-associated nuclear antigen by the
monoclonal antibody Ki-67 allows the determination of the growth fraction in human cell …

The pituitary gland influences osmoregulation, growth, lactation, the immune system and
parturition, and is responsible for regulating thyroid, adrenal and gonadal function. During …