Role of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures

ME Brown, RS El-Mallakh - Therapeutics and clinical risk …, 2010 - Taylor & Francis
Eslicarbazepine is a new dibenzazepine antiepileptic agent. It is a high affinity antagonist of
the voltage-gated sodium channel. It is closely related to both carbamazepine and …

Predictors of seizure freedom, response and retention after 12 months of treatment with eslicarbazepine acetate: A post-hoc analysis of the Euro-Esli study

F Sales, N Delanty, O Mecarelli, M Holtkamp… - Epilepsy Research, 2021 - Elsevier
Eslicarbazepine acetate (ESL) is a once-daily antiseizure medication (ASM) that is approved
in Europe and the USA for the treatment of focal-onset seizures. The Euro-Esli study, which …

Efficacy and safety of eslicarbazepine acetate versus controlled‐release carbamazepine monotherapy in newly diagnosed epilepsy: a phase III double‐blind …

E Trinka, E Ben‐Menachem, PA Kowacs, C Elger… - …, 2018 - Wiley Online Library
Objective We assessed the efficacy and safety of once‐daily eslicarbazepine acetate in
comparison with twice‐daily (BID) controlled‐release carbamazepine (carbamazepine‐CR) …

Pharmacokinetics, efficacy, and tolerability of eslicarbazepine acetate in children and adolescents with epilepsy

L Almeida, I Minciu, T Nunes… - The Journal of …, 2008 - Wiley Online Library
This study investigates the pharmacokinetics of eslicarbazepine acetate (ESL), a new
voltage‐gated sodium channel blocker, in epileptic children aged 2 to 7 years (n= 11) and 7 …

Eslicarbazepine acetate as adjunctive therapy in clinical practice: ESLADOBA study

J Chaves, P Breia, J Pimentel, R Pelejão… - Acta Neurologica …, 2017 - Wiley Online Library
Objective To assess seizure control and tolerability of eslicarbazepine acetate (ESL) as
adjunctive therapy to one baseline antiepileptic drug (AED), in adults with partial‐onset …

Effect of age and gender on the pharmacokinetics of eslicarbazepine acetate

P Soares-da-Silva, L Almeida, A Falcão, J Maia - 2005 - estudogeral.uc.pt
Eslicarbazepine acetate is a novel voltage-gated sodium channel blocker in development
for the treatment of epilepsy, bipolar disorder and neuropathic pain. The objective of this …

ABCB1 c. 3435C> T and EPHX1 c. 416A> G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic …

ML Zhang, XL Chen, ZF Bai, X Zhao, WX Li, XY Wang… - Gene, 2021 - Elsevier
The gene polymorphisms of ABCB1, EPHX1, and SCN1A were found to influence
carbamazepine (CBZ) metabolism and resistance in epilepsy patients, but the relevance …

Safety of Eslicarbazepine Acetate in Patients with Refractory Partial-Onset Seizures Treated With or Without Concomitant Carbamazepine: A Pooled Analysis of Three …

S Benbadis, V Biton, M Jacobson, E Trinka, M Carreño… - Neurology, 2014 - AAN Enterprises
OBJECTIVE: Investigate the safety of eslicarbazepine acetate (ESL) as adjunctive therapy
for partial-onset seizures (POS) with/without concomitant carbamazepine (CBZ) …

Eslicarbazepine acetate: a well-kept secret?

E Ben-Menachem - Epilepsy Currents, 2010 - journals.sagepub.com
Efficacy and Safety of Eslicarbazepine Acetate as Adjunctive Treatment in Adults with
Refractory Partial-Onset Seizures: A Randomized, Double-Blind, Placebo-Controlled …

Safety and efficacy of eslicarbazepine acetate (Zebinix) in everyday clinical practice using a retrospective multicentre audit

S Keogh, P McDonald, C Lawthom… - Journal of Neurology …, 2014 - jnnp.bmj.com
Purpose We report on the safety and efficacy of eslicarbazepine acetate (ESL) in routine
clinical practice. Method Retrospective multicentre audit of outcomes following ESL …