MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

Therapeutic targeting of microRNAs in cancer: future perspectives

L Tutar, E Tutar, A Özgür, Y Tutar - Drug development research, 2015 - Wiley Online Library
ABSTRACT Preclinical Research The discovery of microRNAs (miRNAs) and their link with
cancer has opened a new era in cancer therapeutics. Approximately, 18− 24 nucleotides …

Targeting microRNAs in cancer: rationale, strategies and challenges

R Garzon, G Marcucci, CM Croce - Nature reviews Drug discovery, 2010 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …

Targeting microRNAs in cancer gene therapy

W Ji, B Sun, C Su - Genes, 2017 - mdpi.com
MicroRNAs (miRNAs) are a kind of conserved small non-coding RNAs that participate in
regulating gene expression by targeting multiple molecules. Early studies have shown that …

Recent trends in targeting miRNAs for cancer therapy

V Shah, J Shah - Journal of Pharmacy and Pharmacology, 2020 - academic.oup.com
Objectives MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells
for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the …

microRNAs as cancer therapeutics: A step closer to clinical application

TC Ivkovic, G Voss, H Cornella, Y Ceder - Cancer letters, 2017 - Elsevier
During the last decades, basic and translational research has enabled great improvements
in the clinical management of cancer. However, scarcity of complete remission and many …

microRNA therapeutics in cancer—an emerging concept

MY Shah, A Ferrajoli, AK Sood, G Lopez-Berestein… - …, 2016 - thelancet.com
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding
RNAs that negatively regulate protein coding gene and other non-coding transcripts …

Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments

KKW To, W Fong, CWS Tong, M Wu… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the
expression of their target genes by reducing mRNA stability and/or inhibiting translation …

MiRNA-based therapeutic intervention of cancer

S Naidu, P Magee, M Garofalo - Journal of hematology & oncology, 2015 - Springer
MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting
protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus …

[HTML][HTML] MicroRNA-based cancer therapeutics: big hope from small RNAs

A Bhardwaj, S Singh, AP Singh - Molecular and cellular …, 2010 - ncbi.nlm.nih.gov
Tremendous progress has been made during the last few years in identification of novel
tumor-associated microRNAs and experimental validation of their cancer relevant gene …