Delivering the CRISPR/Cas9 system for engineering gene therapies: Recent cargo and delivery approaches for clinical translation

RA Foley, RA Sims, EC Duggan, JK Olmedo… - … in Bioengineering and …, 2022 - frontiersin.org
Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9
(CRISPR/Cas9) has transformed our ability to edit the human genome selectively. This …

Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing

F Sinclair, AA Begum, CC Dai, I Toth… - Drug delivery and …, 2023 - Springer
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome
editing system has been a major technological breakthrough that has brought revolutionary …

Delivery of CRISPR/Cas9 by novel strategies for gene therapy

L Wang, W Zheng, S Liu, B Li, X Jiang - ChemBioChem, 2019 - Wiley Online Library
Precise editing of the genome of a living body is a goal pursued by scientists in many fields.
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas …

CRISPR/Cas9 delivery system engineering for genome editing in therapeutic applications

H Cheng, F Zhang, Y Ding - Pharmaceutics, 2021 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) systems have emerged as a robust and versatile genome editing platform …

In vivo delivery of CRISPR/Cas9 for therapeutic gene editing: progress and challenges

R Mout, M Ray, YW Lee, F Scaletti… - Bioconjugate …, 2017 - ACS Publications
The successful use of clustered regularly interspaced short palindromic repeat
(CRISPR)/Cas9-based gene editing for therapeutics requires efficient in vivo delivery of the …

[HTML][HTML] In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges

M Behr, J Zhou, B Xu, H Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …

Development of CRISPR/Cas delivery systems for in vivo precision genome editing

Y Chen, Y Ping - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Clustered, regularly interspaced, short palindromic repeat (CRISPR)/associated
protein 9 (CRISPR/Cas9) is emerging as a powerful genome-editing tool, enabling precise …

Progress and challenges towards CRISPR/Cas clinical translation

D Rosenblum, A Gutkin, N Dammes, D Peer - Advanced Drug Delivery …, 2020 - Elsevier
CRISPR/Cas systems (clustered regularly interspaced short palindromic repeats) have
emerged as powerful tools to manipulate the genome for both research and therapeutic …

Delivery of CRISPR/Cas9 for therapeutic genome editing

X Xu, T Wan, H Xin, D Li, H Pan, J Wu… - The journal of gene …, 2019 - Wiley Online Library
The clustered, regularly‐interspaced, short palindromic repeat (CRISPR)‐associated
nuclease 9 (CRISPR/Cas9) is emerging as a promising genome‐editing tool for treating …

[HTML][HTML] CRISPR/Cas9 systems: delivery technologies and biomedical applications

Y Du, Y Liu, J Hu, X Peng, Z Liu - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
The emergence of the clustered regularly interspaced short palindromic repeats
(CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a …