Yersinia pestis causes a rapid, lethal disease referred to as plague. Y. pestis actively inhibits
the innate immune system to generate a noninflammatory environment during early stages …

Pneumonic plague, caused by Yersinia pestis, is characterized by bacterial evasion and
manipulation of the mammalian innate immune system. Following an initial anti …

Virulence of Yersinia pestis in mammals requires the type III secretion system, which
delivers seven effector proteins into the cytoplasm of host cells to undermine immune …

Inhalation of Yersinia pestis causes primary pneumonic plague, the most severe
manifestation of plague that is characterized by a dramatic neutrophil influx to the lungs …

Human polymorphonuclear leukocytes (PMNs, or neutrophils) are the primary innate host
defense against invading bacterial pathogens. Neutrophils are rapidly recruited to sites of …

Yersinia pestis is a gram-negative, zoonotic, bacterial pathogen, and the causative agent of
plague. The bubonic form of plague occurs subsequent to deposition of bacteria in the skin …

The human and animal pathogens Yersinia pestis, which causes bubonic and pneumonic
plague, and Yersinia pseudotuberculosis and Yersinia enterocolitica, which cause …

Human polymorphonuclear leukocytes (PMNs, or neutrophils) are the most abundant innate
immune cell and kill most invading bacteria through combined activities of reactive oxygen …

ABSTRACT A Yersinia pestis-human protein interaction network is reported here to improve
our understanding of its pathogenesis. Up to 204 interactions between 66 Y. pestis bait …

Yersinia pestis evades immune responses in part by injecting into host immune cells several
effector proteins called Yersinia outer proteins (Yops) that impair cellular function. This has …