IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic
inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling …

Signal transduction in response to interleukin‐6 (IL‐6) requires binding of the cytokine to its
receptor (IL‐6R) and subsequent homodimerization of the signal transducer gp130. The …

Binding of interleukin-6 (IL-6) to its specific receptor IL-6R is a prerequisite for the activation
of the signal-transducing receptor glycoprotein 130 (gp130). A soluble form of the IL-6R (sIL …

Interleukin (IL-) 6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals
via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R) …

Soluble forms of the IL-6 receptor (sIL-6R) bind to the cytokine IL-6 with similar affinity as the
membrane-bound IL-6R. IL-6· sIL-6R complexes initiate IL-6 trans-signaling via activation of …

IL-6 mediates its pleiotropic functions through two membrane proteins, a ligand-binding
molecule (IL-6 receptor, IL-6R) and a non-ligand-binding signal transducer (gp130). Starting …

Abstract Interleukin-6 (IL-6) is considered an inflammatory cytokine, which is involved not
only in most inflammatory states but it also plays a prominent role in inflammation associated …

Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …

Soluble gp130 is the natural inhibitor of trans-signaling mediated by the soluble IL-6/IL-6R
complex. In mouse models, recombinant sgp130 has been successfully applied for the …

The successful treatment of certain autoimmune conditions with the humanized anti–IL-6
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …