We have investigated the effects of combination treatment involving ERL (erlotinib) with a
glycyrrhetinic acid analog, CDODA-Me in overcoming ERL resistance, providing efforts to …

Lung cancer is still one of the leading causes of malignancy related deaths worldwide
despite recent advances in diagnosis and therapy. Among various biomarkers detected in …

The aim of the present investigation was to deliver Gemcitabine Hydrochloride (GmcH), an
anticancer bioactive, specifically to lung tumor cells using mannosylated 4.0 G poly …

The formulation of nanoscale systems with well-defined sizes and shapes is of great interest
in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are …

The aim of the present study was to use a combinatorial approach of inclusion complexation
and dendrimer synthesization of gefitinib using solvent-free technique for targeting EGFR-TK …

Dendrimers have proven to be effective for drug delivery and their biodisposition varies with
change on their surface, generation and core. In an effort to understand the role of critical …

Purpose Erlotinib (ETB) is a well-established therapeutic for non-small-cell lung cancer
(NSCLC). To overcome drug resistance and severe toxicities in the clinical application …

Dendrimers in nanobiomedicine have attracted attention to overcome the biological barriers
because of their suitable characteristics such as nanosize, hyperbranching polymeric …

Background Inhalation of chemotherapeutic drugs directly into the lungs augments the drug
exposure to lung cancers. The inhalation of free drugs however results in over exposure and …

The fourth generation (G4) of poly (amidoamine) dendrimer was PEGylated and then
physically incorporated with carboplatin to develop the new drug delivery carrier. The proton …