With increase in women's age, the reproductive capability of female mammals decreases
dramatically caused by age-related oxidative stress, coinciding with the decline in the …

Oxidative stress is known as a major contributing factor involved in oocyte aging, which
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …

The quality of metaphase II oocytes deteriorates rapidly following ovulation as the result of
an aging process associated with impaired fertilizing potential, disrupted developmental …

The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration
as a result of the aging process. Melatonin is considered to be an anti-aging agent …

Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

Melatonin (MT) can improve the effect of cryopreservation on oocytes by suppressing
oxidative stress and maintaining the permeability of the oolemma. In this study, MT was …

Female fertility irreversibly declines with aging, and this is primarily associated with the
decreased quality and quantity of oocytes. To evaluate whether a long‐term of melatonin …

Melatonin is a well‐characterized antioxidant that has been successfully used to protect
oocytes from reactive oxygen species during in vitro maturation (IVM), resulting in improved …

After reaching the metaphase II (MII) stage, unfertilised oocytes undergo a time-dependent
process of quality deterioration referred to as oocyte aging. The associated morphological …

Melatonin secreted via the pineal gland has been proven to have strong antioxidant activity.
In addition to its activity as a neuroendocrine hormone through receptors, its relationship …