Human T-Cell Leukemia Virus Type 1 Oncogenesis between Active Expression and Latency: A Possible Source for the Development of Therapeutic Targets

F Marino-Merlo, S Grelli, A Mastino, M Lai… - International Journal of …, 2023 - mdpi.com
The human T-cell leukemia virus type 1 (HTLV-1) is the only known human oncogenic
retrovirus. HTLV-1 can cause a type of cancer called adult T-cell leukemia/lymphoma (ATL) …

Molecular biology of human T cell leukemia virus

L Ratner - Seminars in diagnostic pathology, 2020 - Elsevier
Human T cell leukemia virus type 1 (HTLV-1) is a horizontally transmitted virus infection of
CD4+ lymphocytes which causes adult T cell leukemia-lymphoma (ATLL) and HTLV …

Human T-cell leukemia virus type 1: replication, proliferation and propagation by Tax and HTLV-1 bZIP factor

M Matsuoka, J Yasunaga - Current opinion in virology, 2013 - Elsevier
Highlights•HTLV-1 primarily transmits by cell-to-cell contact.•HTLV-1 increases the number
of infected cells by clonal proliferation to facilitate its transmission.•HTLV-1 bZIP factor (HBZ) …

HTLV-1 alters T cells for viral persistence and transmission

A Tanaka, M Matsuoka - Frontiers in microbiology, 2018 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus to be discovered as a
causative agent of adult T-cell leukemia-lymphoma (ATL) and chronic inflammatory …

Mouse Models for HTLV-1 Infection and Adult T Cell Leukemia

S Nakajima, K Okuma - International Journal of Molecular Sciences, 2023 - mdpi.com
Adult T cell leukemia (ATL) is an aggressive hematologic disease caused by human T cell
leukemia virus type 1 (HTLV-1) infection. Various animal models of HTLV-1 infection/ATL …

Strategies of human T-cell leukemia virus Type 1 for persistent infection: Implications for leukemogenesis of adult T-cell leukemia-lymphoma

J Yasunaga - Frontiers in microbiology, 2020 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) establishes persistent infection in vivo in two
distinct ways: de novo infection and clonal proliferation of infected cells. Two viral genes …

HTLV-1 infection and adult T-cell leukemia/lymphoma—a tale of two proteins: tax and HBZ

CZ Giam, OJ Semmes - Viruses, 2016 - mdpi.com
HTLV-1 (Human T-cell lymphotropic virus type 1) is a complex human delta retrovirus that
currently infects 10–20 million people worldwide. While HTLV-1 infection is generally …

HTLV-1 HBZ viral protein: a key player in HTLV-1 mediated diseases

M Baratella, G Forlani, RS Accolla - Frontiers in microbiology, 2017 - frontiersin.org
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus that has
infected 10–15 million people worldwide. After a long latency, 3–5% of infected individuals …

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

HBZ and its roles in HTLV-1 oncogenesis

T Zhao, M Matsuoka - Frontiers in microbiology, 2012 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus
strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ) …