MyoD is sufficient to initiate the skeletal muscle gene expression program. Transcription of
certain MyoD target genes occurs in the early phases, whereas that of others is induced only …

We used a combination of genome‐wide and promoter‐specific DNA binding and
expression analyses to assess the functional roles of Myod and Myog in regulating the …

Recent studies have demonstrated that MyoD initiates a feed-forward regulation of skeletal
muscle gene expression, predicting that MyoD binds directly to many genes expressed …

Most of the genes that are central to the process of skeletal muscle differentiation remain in a
transcriptionally silent or “off” state until muscle cells (myoblasts) are induced to differentiate …

Acetylation is a post‐translational modification that influences the activity of numerous
proteins in vitro. Among them, the myogenic transcription factor MyoD shows an increased …

MYOD is a master regulator of the skeletal myogenic program. But what regulates
expression of Myod? More than 20 years ago, studies established that Myod expression is …

While chromatin modifications can offer a useful readout for enhancer activities, it is less
clear whether these modification marks are a cause or consequence of transcription factor …

MyoD1 is a key regulator that orchestrates skeletal muscle differentiation through the
regulation of gene expression. Although many studies have focused on its role in …

To identify the compendium of distal regulatory elements that govern myogenic
differentiation, we generated chromatin state maps based on histone modifications and …

Background: Among the complexities of skeletal muscle differentiation is a temporal
distinction in the onset of expression of different lineage‐specific genes. The lineage …