[PDF][PDF] Characterization of the new htau-KI mouse model for Alzheimer's disease with a focus on the role of immune cells during progressing cerebral amyloidosis

S Barendrecht - 2021 - opendata.uni-halle.de
1.1 Background of Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative
disorder, first presented by the German physician Alois Alzheimer in 1906. In the 4 …

A TauP301L mouse model of dementia; development of pathology, synaptic transmission, microglial response and cognition throughout life

Z Joel, P Izquierdo, W Liu, C Hall, M Roberts, K Yap… - BioRxiv, 2018 - biorxiv.org
Abstract Background Late stage Alzheimer's disease and other dementias are associated
with neurofibrillary tangles and neurodegeneration. Here we describe a mouse (TauD35) …

EXPERIMENTAL MODELS OF ALZHEIMER'S DISEASE

AM ERCAN - Alzheimer's Disease From Molecular Mechanisms to … - books.google.com
Alzheimer's disease (AD) is becoming increasingly common as the global population ages.
The World Health Organization (WHO) estimates that 1 billion people were over the age of …

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease

I St-Amour, CR Bosoi, I Paré… - Journal of …, 2019 - Springer
Background Immunologic abnormalities have been described in peripheral blood and
central nervous system of patients suffering from Alzheimer's disease (AD), yet their role in …

Modeling Alzheimer's disease: considerations for a better translational and replicable mouse model

JD Cho, M Yang, I Santa-Maria - Neural Regeneration Research, 2022 - journals.lww.com
Alzheimer's disease (AD) mouse models have proven to be an invaluable tool for deepening
our understanding of disease mechanisms and for developing therapeutics. However, one …

[HTML][HTML] Characterization of Transgenic Mouse Models of Alzheimer's Disease and Related Dementia

LC Camargo - docserv.uni-duesseldorf.de
Beschreibungen: Alzheimer's disease (AD) is a complex neurodegenerative disorder with
multiple features. With the help of animal models, the AD physiopathology is starting to be …

Animal models of Alzheimer's disease

S Amram, D Frenkel - Neuroprotection in Alzheimer's Disease, 2017 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia. The pathological
characterizations of AD are the depositions of a peptide called amyloid beta and of hyper …

[HTML][HTML] Murine models of Alzheimer's disease and their use in developing immunotherapies

T Wisniewski, EM Sigurdsson - … et Biophysica Acta (BBA)-Molecular Basis …, 2010 - Elsevier
Alzheimer's disease (AD) is one of the categories of neurodegenerative diseases
characterized by a conformational change of a normal protein into a pathological conformer …

[HTML][HTML] Animal models of Alzheimer's disease

G Casadesus, G Arendash, F Laferla… - International journal of …, 2010 - ncbi.nlm.nih.gov
The necessity for a deeper understanding of neurological diseases such as Alzheimer's
disease (AD) that increase in frequency as a function of age has become of paramount …

Mouse models of Alzheimer's disease

M Yokoyama, H Kobayashi, L Tatsumi… - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …