Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune
cells as well as cardiac smooth muscle cells and endothelial cells. Its activation exhibits to …

Chronic low-grade inflammation contributes to the development of several diseases,
including cardiovascular disease. Adequate strategies to target inflammation in …

The P2X7 receptor is a ligand‐gated purinergic receptor activated by extracellular ATP. The
receptor is highly expressed in immune cells and in the brain, and, upon activation, the …

Purpose Low-grade inflammation contributes to heart failure in obesity or type 2 diabetes
mellitus. The P2X7 receptor (P2X7R) is a key regulator of several pro-inflammatory …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

The purinergic P2X7 receptor (P2X7R), an ATP-gated non-selective cation channel, has
emerged as a gatekeeper of inflammation that controls the release of proinflammatory …

Abstract P2X7 receptor (P2X7R), a distinct ligand-gated ion channel, is a member of
purinergic type 2 receptor family with ubiquitous expression in human body. Previous …

P2X7 receptor is an ion channel activated by extracellular adenosine trisphosphate (eATP)
that attracted increasing attention for its role in immune reactions, neurobiology and …

P2X receptors are ATP‐gated cation channels that mediate fast excitatory transmission in
diverse regions of the brain and spinal cord. Several P2X receptor subtypes, including …

The P2X7 purinergic receptor, a calcium permeable cationic channel, is activated by
extracellular ATP. Most studies show that P2X7 receptor plays an important role in the …