Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer.
SCLC progression and treatment resistance involve epigenetic processes. However, links …

DNA methylation is a key regulator of gene expression and a clinical therapeutic predictor.
We examined global DNA methylation beyond the generally used promoter areas in human …

Small cell lung cancer (SCLC) is a disease characterized by aggressive clinical behavior
and lack of effective therapy. Owing to its tendency for early dissemination, only a third of …

Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early
metastasis, rapid development of resistance to chemotherapy and genetic instability. This …

Background DNA methylation is associated with aberrant gene expression in cancer, and
has been shown to correlate with therapeutic response and disease prognosis in some …

Epigenetic alterations are widespread in cancer and can complement genetic alterations to
influence cancer progression and treatment outcome. To determine the potential …

Purpose: Lung cancer is the worldwide leading cause of death from cancer. DNA
methylation in gene promoter regions is a major mechanism of gene expression regulation …

Background: Aberrant DNA methylation occurs commonly during carcinogenesis and is of
clinical value in human cancers. However, knowledge of the impact of DNA methylation …

Background Epigenetic alterations are strongly associated with the development of cancer.
The aim of this study was to identify epigenetic pattern in squamous cell lung cancer (LUSC) …

Small-cell lung cancer (SCLC) methylome is understudied. Here, we comprehensively
profile SCLC using cell-free methylated DNA immunoprecipitation followed by sequencing …