CYP2B6 Non-Coding Variation Associated with Smoking Cessation Is Also Associated with Differences in Allelic Expression, Splicing, and Nicotine Metabolism …
The Cytochrome P450 2B6 (CYP2B6) enzyme makes a small contribution to hepatic
nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for …
nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for …
Gene–gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism
Objectives CYP2A6 is the major enzyme involved in nicotine metabolism, yet large
interindividual variations in the rate of nicotine metabolism exist within groups of individuals …
interindividual variations in the rate of nicotine metabolism exist within groups of individuals …
Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism
N Al Koudsi, RF Tyndale - Xenobiotica, 2010 - Taylor & Francis
Human cytochrome P4502B6 (CYP2B6) is predominantly expressed in the liver and it plays
a major role in the metabolism of several therapeutically important drugs and environmental …
a major role in the metabolism of several therapeutically important drugs and environmental …
CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy
PRX Tomaz, JR Santos, JS Issa, TO Abe… - European journal of …, 2015 - Springer
Background Previous studies suggested that polymorphisms in the CYP2B6 gene (which
encodes an isoenzyme that metabolizes bupropion) and in the ANKK1 gene (which is …
encodes an isoenzyme that metabolizes bupropion) and in the ANKK1 gene (which is …
Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence
V Malaiyandi, EM Sellers… - Clinical Pharmacology & …, 2005 - Wiley Online Library
Nicotine is the primary addictive compound in tobacco smoke. In this review we summarize
nicotine dependence and the genetics of smoking in brief before focusing on cytochrome …
nicotine dependence and the genetics of smoking in brief before focusing on cytochrome …
Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes
Bupropion is used clinically to treat depression and to promote smoking cessation. It is
metabolized by CYP2B6 to its active metabolite hydroxybupropion, yet alterations in …
metabolized by CYP2B6 to its active metabolite hydroxybupropion, yet alterations in …
CYP2A6 polymorphisms may strengthen individualized treatment for nicotine dependence
YM Akrodou - Scientifica, 2015 - Wiley Online Library
Each CYP2A6 gene variant metabolizes nicotine differently depending on its enzymatic
activities. The normal nicotine metabolizer CYP2A6* 1A is associated with high scores of …
activities. The normal nicotine metabolizer CYP2A6* 1A is associated with high scores of …
Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism
Objectives Smoking patterns and cessation rates vary widely across smokers and can be
influenced by variation in rates of nicotine metabolism [ie cytochrome P450 2A6 (CYP2A6) …
influenced by variation in rates of nicotine metabolism [ie cytochrome P450 2A6 (CYP2A6) …
Pharmacogenetic investigation of smoking cessation treatment
C Lerman, PG Shields, EP Wileyto… - Pharmacogenetics …, 2002 - journals.lww.com
Despite the efficacy of bupropion for smoking cessation, smokers exhibit variability in
treatment outcome. The CYP2B6 gene has been implicated in bupropion kinetics and …
treatment outcome. The CYP2B6 gene has been implicated in bupropion kinetics and …
Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles
The human microsomal cytochrome P450, CYP2B6, is involved in the biotransformation of
several clinically important drugs. By complete sequence analysis of the human CYP2B6 …
several clinically important drugs. By complete sequence analysis of the human CYP2B6 …